Symbol: HFI1 Name: Histone H2A Functional Interactor 1 Alias: ADA1;SUP110;SRM12;GAN1 Entrez gene ID: 855821 Ensembl gene ID: YPL254W Species: Yeast (Taxid: 4932) Functional description: Hfi1p; Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions [Source:SGD;Acc:S000006175] [Ensembl] Observation: ADA1 deletion shortens replicative lifespan by approximately 80%. This is not a premature aging phenotype as ADA1 cells do not become prematurely sterile or shibit other biomarkers of aging. ADA1 mutants are temperature-sensitive and respiratory-deficent. Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Note: I have no access to the paper. Edit \ Update (Admin) | Delete |
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