Symbol: HHF1
Name: Histone H Four 1
Entrez gene ID: 852294
Ensembl gene ID: YBR009C
Species: Yeast
(Taxid: 4932)
Functional description:
Hhf1p; Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity [Source:SGD;Acc:S000000213] [Ensembl]
Observation:
HHF1 deletion extends mean and maximum replicative by 45 and 69%, respectively, as well as chronological lifespan. Chronological lifespan extension by HHF1 deletion and DR is non-synergistic. DR appears to extend replicative lifespan more when combined with hhf1 mutation, whereas DR does not change hhf1-induced replicative lifespan extension, suggesting a positive interaction [21584246].
Interventions:
HHF1 deletion
Assays:
Replicative Lifespan
Chronological Lifespan
Mean: +45
Maximum: +69
Classification:
Gerontogene
Positive Gerontogene
DR-Essential
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
HIST1H4F
(9606)
HIST2H4B
(9606)
HIST1H4J
(9606)
HIST4H4
(9606)
HIST1H4K
(9606)
HIST1H4A
(9606)
HIST1H4L
(9606)
HIST1H4H
(9606)
HIST2H4A
(9606)
HIST1H4B
(9606)
HIST1H4E
(9606)
HIST1H4C
(9606)
HIST1H4D
(9606)
HIST1H4I
(9606)
LOC735611
(9598)
LOC465305
(9598)
LOC736707
(9598)
LOC457262
(9598)
LOC748532
(9598)
LOC462507
(9598)
LOC748540
(9598)
LOC472228
(9598)
LOC748545
(9598)
LOC748525
(9598)
LOC748513
(9598)
LOC611513
(9615)
LOC525863
(9913)
LOC679840
(10116)
LOC417946
(9031)
H4-VII
(9031)
LOC770005
(9031)
LOC770142
(9031)
LOC770079
(9031)
LOC427884
(9031)
zgc:153409
(7955)
His4:CG33881
(7227)
His4:CG33869
(7227)
His4:CG33879
(7227)
His4:CG33877
(7227)
hhf1
(4896)
hhf2
(4896)
hhf3
(4896)
HHF1
(4932)
HHF2
(4932)
KLLA0E08613g
(28985)
KLLA0E08647g
(28985)
AGOS_ADL201W
(33169)
GeneID:2684448
(148305)
GeneID:2675181
(148305)
NCU00212
(5141)
NCU01634
(5141)
AT5G59690
(3702)
HIS4
(3702)
AT5G59970
(3702)
AT3G45930
(3702)
AT3G46320
(3702)
AT3G53730
(3702)
AT1G07660
(3702)
AT1G07820
(3702)
Os01g0835900
(4530)
PF11_0061
(5833)
Orthologs
His4:CG33905
(7227)
His4:CG33899
(7227)
His4:CG33875
(7227)
His4:CG33883
(7227)
LOC679983
(10116)
Hist1h4c
(10090)
his-50
(6239)
his-28
(6239)
his-18
(6239)
his-26
(6239)
Hist1h4n
(10090)
His4:CG33887
(7227)
HIST1H4I
(9606)
His4:CG33891
(7227)
His4:CG33897
(7227)
his-37
(6239)
hhf2
(4896)
HIST4H4
(9606)
HIST1H4A
(9606)
HIST1H4D
(9606)
HIST1H4F
(9606)
HIST1H4K
(9606)
HIST1H4J
(9606)
HIST1H4C
(9606)
HIST1H4H
(9606)
HIST1H4B
(9606)
HIST1H4E
(9606)
HIST1H4L
(9606)
HIST2H4A
(9606)
his-1
(6239)
Hist1h4f
(10090)
his-10
(6239)
His4:CG33901
(7227)
his-31
(6239)
LOC698354
(9544)
his-38
(6239)
his-5
(6239)
His4:CG33873
(7227)
LOC696253
(9544)
His4:CG33881
(7227)
His4:CG33907
(7227)
RGD1565073
(10116)
Hist1h4h
(10090)
His4:CG33885
(7227)
His4:CG33871
(7227)
His4r
(7227)
His4:CG33877
(7227)
HIST2H4B
(9606)
His4:CG33903
(7227)
his-60
(6239)
his-67
(6239)
His4:CG31611
(7227)
hhf1
(4896)
his-46
(6239)
his-56
(6239)
his-64
(6239)
His4:CG33893
(7227)
His4:CG33889
(7227)
His4:CG33879
(7227)
LOC679840
(10116)
His4:CG33895
(7227)
his-14
(6239)
HIST1H4G
(9606)
His4:CG33869
(7227)
hhf3
(4896)
LOC699317
(9544)
Hist1h4a
(10090)
His4:CG33909
(7227)
His4:CG33905
(7227)
His4:CG33899
(7227)
His4:CG33875
(7227)
His4:CG33883
(7227)
LOC679983
(10116)
Hist1h4c
(10090)
his-50
(6239)
his-28
(6239)
his-18
(6239)
his-26
(6239)
Hist1h4n
(10090)
His4:CG33887
(7227)
HIST1H4I
(9606)
His4:CG33891
(7227)
His4:CG33897
(7227)
his-37
(6239)
hhf2
(4896)
HHF2
(4932)
HIST4H4
(9606)
HIST1H4A
(9606)
HIST1H4D
(9606)
HIST1H4F
(9606)
HIST1H4K
(9606)
HIST1H4J
(9606)
HIST1H4C
(9606)
HIST1H4H
(9606)
HIST1H4B
(9606)
HIST1H4E
(9606)
HIST1H4L
(9606)
HIST2H4A
(9606)
his-1
(6239)
Hist1h4f
(10090)
his-10
(6239)
His4:CG33901
(7227)
his-31
(6239)
LOC698354
(9544)
his-38
(6239)
his-5
(6239)
His4:CG33873
(7227)
LOC696253
(9544)
His4:CG33881
(7227)
His4:CG33907
(7227)
RGD1565073
(10116)
Hist1h4h
(10090)
His4:CG33885
(7227)
His4:CG33871
(7227)
His4r
(7227)
His4:CG33877
(7227)
HIST2H4B
(9606)
His4:CG33903
(7227)
his-60
(6239)
his-67
(6239)
His4:CG31611
(7227)
hhf1
(4896)
his-46
(6239)
his-56
(6239)
his-64
(6239)
His4:CG33893
(7227)
His4:CG33889
(7227)
His4:CG33879
(7227)
LOC679840
(10116)
His4:CG33895
(7227)
his-14
(6239)
HIST1H4G
(9606)
His4:CG33869
(7227)
hhf3
(4896)
LOC699317
(9544)
Hist1h4a
(10090)
His4:CG33909
(7227)
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