Symbol: SFA1
Name: Sensitive to FormAldehyde 1
Alias: ADH5
Entrez gene ID: 851386
Ensembl gene ID: YDL168W
Species: Yeast
(Taxid: 4932)
Functional description:
Sfa1p; Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p [Source:SGD;Acc:S000002327] [Ensembl]
Observation:
sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis is crucial during DR-induced replicative lifespan extension. Deleting YHB1 partially abolishes the DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246].
Interventions:
SFA1 deletion
SFA1 YHB1 double mutation
Assays:
Replicative Lifespan
Classification:
DR-Essential
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
ADH5
(9606)
ADH5
(9598)
ADH5
(9913)
Adh5
(10090)
ADH5
(9031)
adh5
(7955)
Fdh
(7227)
AgaP_AGAP010499
(7165)
H24K24.3
(6239)
Y50D4C.2
(6239)
SPCC13B11.04c
(4896)
SFA1
(4932)
KLLA0D12342g
(28985)
AGOS_ACL148C
(33169)
GeneID:2683964
(148305)
NCU06652
(5141)
HOT5
(3702)
Os02g0815500
(4530)
Orthologs
ADH5
(9606)
ADH7
(9544)
Adh1
(10090)
ADH7
(9606)
Adh7
(10090)
Adh5
(10090)
ADH6
(9606)
ADH6
(9544)
ADH1A
(9606)
ADH4
(9544)
ADH5
(9544)
Y50D4C.2
(6239)
Adh7
(10116)
SPCC13B11.04c
(4896)
Fdh
(7227)
LOC697703
(9544)
Adh6a
(10116)
H24K24.3
(6239)
Adh4
(10116)
Adh1
(10116)
ADH1C
(9544)
ADH1B
(9606)
Adh6
(10116)
Adh4
(10090)
Adh6a
(10090)
ADH4
(9606)
ADH5
(9606)
ADH7
(9544)
Adh1
(10090)
ADH7
(9606)
Adh7
(10090)
Adh5
(10090)
ADH6
(9606)
ADH6
(9544)
ADH1A
(9606)
ADH4
(9544)
ADH5
(9544)
Y50D4C.2
(6239)
Adh7
(10116)
SPCC13B11.04c
(4896)
Fdh
(7227)
LOC697703
(9544)
Adh6a
(10116)
H24K24.3
(6239)
Adh4
(10116)
Adh1
(10116)
ADH1C
(9544)
ADH1B
(9606)
Adh6
(10116)
Adh4
(10090)
Adh6a
(10090)
ADH4
(9606)
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