Symbol: ERG2 Name: ERGosterol biosynthesis 2 Alias: END11 Entrez gene ID: 855242 Ensembl gene ID: YMR202W Species: Yeast (Taxid: 4932) Functional description: Erg2p; C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis [Source:SGD;Acc:S000004815] [Ensembl] Observation: Overexpression of ERG2 with the promoter of ERG6 (Perg6-ERG2) extends replicative lifespan and this effect was overlapping with moderate DR, because DR can not extend the lifespan of this mutant [Tang et al., unpublished]. Perg6-ERG2 does not extend the lifespan significantly on normal medium, but it reverses the effect of DR. DR greatly shortens the lifespan of Perg6-ERG2 mutants. Perg6-ERG2 shortens the lifespan of nyv1 deletion mutations [Xia et al. unpublished]. Deletion of OSH5 greatly shortens the lifespan of Perg6-ERG2. SIR2 overxpression extends the lifespan of Perg6-ERG2 [Xia et al. unpublished]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Note: Perg6-ERG2 does not extend the lifespan significantly on normal medium, is probaly wrong as it extends the lifespan. Edit \ Update (Admin) | Delete |
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