Symbol: FKH1 Name: ForK head Homolog 1 Entrez gene ID: 854675 Ensembl gene ID: YIL131C Species: Yeast (Taxid: 4932) Functional description: Fkh1p; Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching [Source:SGD;Acc:S000001393] [Ensembl] Observation: Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [18225956]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [22438832]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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