Symbol: cyc-1 Name: Cytochrome c1 Entrez gene ID: 172582 Ensembl gene ID: C54G4.8 Species: Worm (Taxid: 6239) Functional description: Protein CYC-1; CYtochrome C family member (cyc-1) [Source:RefSeq peptide;Acc:NP_492207] [Ensembl]; cyc-1 encodes a component of complex III ( cytochrome c reductase) required for normal ATP production; reduction of ATP production by cyc-1(RNAi) decreases growth rate and body size, slows behavior, and increases lifespan; cyc-1 encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial [WormBase] Observation: RNA interference of cyc-1 results in a 45-87% increase in mean lifespan [16103914]. cyc-1 RNAi extends mean and maximum lifespan by 66 and 79%, respectively. RNAi of cyc-1 during larval stages is necessary and sufficient for lifespan extension, while RNAi of cyc-1 only during the adulthood fails to extend lifespan [12471266]. RNAi against cyc-1 increases mean and 75th %ile lifespan by 8-28 and 16-29%, respectively [22560223]. cyc-1 RNAi results in reduced pharyngeal pumping, defection, motility, ATP levels (by 60-80%), an body size. Mutation of daf-16 fails to prevent lifespan extenison by RNAi of cyc-1 and mutation of daf-2 further extends the lifespan of cyc-1 RNAi animals [12471266]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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