Symbol: MUP1 Name: Methionine UPtake 1 Entrez gene ID: 852946 Ensembl gene ID: YGR055W Species: Yeast (Taxid: 4932) Functional description: Mup1p; High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake [Source:SGD;Acc:S000003287] [Ensembl] Observation: Deletion of MUB1 extends mean and maximum replicative lifespan by 29 - 48% (29,48,43) and 20 - 23% (20,20,23), respectively. Mub1 is necessary for Ubr2-mediated Rpn4 ubiquitination. Lifespan extension conferred by MUP1 deletion is abrogated by RPN4 deletion, but not YAP1 deletion [21931558]. Assays: Mean: +29-48 Maximum: +20-23 Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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