Symbol: utx-1 Name: human UTX (Ubiquitously transcribed TPR on X) homolog Entrez gene ID: 181110 Ensembl gene ID: D2021.1 Species: Worm (Taxid: 6239) Functional description: Protein UTX-1; human UTX (Ubiquitously transcribed TPR on X) homolog family member (utx-1) [Source:RefSeq peptide;Acc:NP_509450] [Ensembl]; utx-1 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase, required for embryonic viability and vulval development, and for high brood sizes, locomotion, and growth sizes; UTX-1 contains a JmjC domain, is orthologous to human UTX and UTY, and is paralogous to human JMJD3; by orthology, UTX-1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes. The domain organization of UTX-1 is more similar to human UTX and UTY (each of which, in addition to a sole JmjC domain, also has six tandem N-terminal tetratricopeptide repeats apiece) than to human JMJD3 (which has a sole JmjC domain). By its homology to human UTX, UTX-1 is also expected to associate with the MLL2 homolog SET-16. [WormBase] Observation: utx-1 RNAi extended mean lifespan by 30%, dependent on DAF-16 activity and not additive in daf-2 mutants [21803287]. utx-1 heterogous knockout also extended lifespan. Assays: Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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