Symbol: cm Name: carmine Entrez gene ID: 31647 Ensembl gene ID: FBgn0000330 Species: Fly (Taxid: 7227) Functional description: u-subunit of AP-3 complex; carmine; carmine [Source:FlyBase gene name;Acc:FBgn0000330] [Ensembl]; The gene carmine is referred to in FlyBase by the symbol Dmel\cm (CG3035, FBgn0000330). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; regulation of alternative nuclear mRNA splicing, via spliceosome; ommochrome biosynthetic process; neurogenesis. 15 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; mesothoracic tergum; rhabdomere; eye; wing; secondary pigment cell pigment granule; tertiary pigment cell pigment granule; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Clathrin adaptor, mu subunit; Clathrin adaptor, mu subunit, C-terminal; Clathrin adaptor, mu subunit, conserved site; Longin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages. [FlyBase] Observation: Loss-of-function mutation in cm reduces mean lifespan by 43 - 53% and maximum lifespan by 40 - 44% [17435236]. Interventions: Assays: Organismal Lifespan Mean: -43 to -53 Maximum: -40 to -44 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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