YUH1

Symbol: YUH1
Name: Yeast Ubiquitin Hydrolase 1
Entrez gene ID: 853562
Species: Yeast (Taxid: 4932)

Functional description:
Yuh1p; Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p [Source:SGD;Acc:S000003860] [Ensembl]

Observation:

Deletion of YUH1 decreases replicative lifespan decreased 30% in the alpha strain [18340043].



Interventions:
  • YUH1 deletion -30%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • UCHL3 (9606)
  • UCHL3 (9615)
  • UCHL3 (9913)
  • Uchl3 (10090)
  • Uchl3 (10116)
  • Uchl3-ps1 (10116)
  • UCHL3 (9031)
  • uchl3 (7955)
  • Uch (7227)
  • AgaP_AGAP012113 (7165)
  • uch1 (4896)
  • YUH1 (4932)
  • KLLA0E09967g (28985)
  • AGOS_AGL314C (33169)
  • GeneID:2679360 (148305)
  • NCU06372 (5141)
  • UCH3 (3702)
  • Os02g0654500 (4530)
  • PF14_0576 (5833)



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