Symbol: Wrn Entrez gene ID: 22427 Ensembl gene ID: ENSMUSG00000031583 Species: Mouse (Taxid: 10090) Function: DNA helicase/exonuclease Observation: Mice lacking the helicase domain of the WRN ortholog exhibit many phenotypic features of Werner Syndrom, including a pro-oxidant status and a shorter mean lifespan. Mice with a deletion in the helicase domain [9789047] recapitulates most of the Werner syndrome phenotypes, including an abnormal hyaluronic acid excretion, higher reactive oxygen species levels, dyslipidemia, increased genomic instability, and cancer incidence. Wrn(Dehl/Dehl) mutant mice have a 10 - 15% decrease in their mean lifespan [12707040; 19741171]. Interventions: Assays: Organismal Lifespan Mean: -10 to -15 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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