Symbol: AVT1 Name: Amino acid Vacuolar Transport 1 Entrez gene ID: 853457 Ensembl gene ID: YJR001W Species: Yeast (Taxid: 4932) Function: AVT1 is a a neutral amino acid transporter [11274162]. Observation: Overexpressing or deleting AVT1 is sufficient to extend or shorten replicative lifespan, respectively [23172144]. Overexpression of AVT1 prevents mitochondrial dysfunction, prevents alterations in mitochondrial structure and ΔΨ of aged cells even through the vacuolar acidity is reduced in these cells. AVT1 overexpression extends the mean, median and maximum replicative lifespan by 28, 28, and 22%, respectively [23172144]. Deletion of AVT1 accelerates the development of age-induced mitochondrial dysfunction without effecting the kinetics of vacuolar acidity decline and prevents the suppression of mitochondrial dysfunction by VMA1 and VPH2 overexpression without affecting vacuolar acidity. AVT1 deletion decreases mean, median and maximum replicative lifespan by 21, 22, and 12%, respectively [23172144]. Interventions: Assays: Replicative Lifespan Mean: -20.6 to +27.8 Median: -22.4 to +27.6 Maximum: -11.8 to +21.6 Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit