Symbol: rab-5 Name: RAB family 5 Entrez gene ID: 172755 Ensembl gene ID: F26H9.6 Species: Worm (Taxid: 6239) Functional description: Protein RAB-5; RAB family member (rab-5) [Source:RefSeq peptide;Acc:NP_492481] [Ensembl]; rab-5 encodes the C. elegans Rab5 GTPase ortholog; RAB-5 activity is required for receptor-mediated yolk endocytosis and for phagosome maturation involved in apoptotic cell clearance; rab-5 mutations also affect localization of P granules and PAR-2, as well as the cytoplasmic appearance of cells in the early embryo and larval development; RAB-5 localizes to early endosomes and maturing phagosomes. [WormBase] Observation: rab-5 RNAi in the adulthood reduces mean and maximum lifespan by 38 and 50% [23144747]. Interventions: Assays: Organismal Lifespan Mean: -38.0 Maximum: -50.0 Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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