Symbol: SIRT1
Name: sirtuin 1
Entrez gene ID: 23411
Ensembl gene ID: ENSG00000096717
Species: Human
(Taxid: 9606)
Observation:
SIRT1 was found to be associated with longevity [21972126; 16257164; 16257164; 16257164; 16257164; 16257164; 21972126; 20633545]. SIRT1 was not found to be associated with longevity [16257164; 18765803].SIRT1 was found to be associated with longevity [23505545]. SIRT1 was found to be associated with longevity [23450480]. SIRT1 was not found to be associated with longevity [23450480].
Assays:
Organismal Lifespan
Longevity Associated Variants:
rs3758391 1.0 [16257164]
rs1885472 1.0 [16257164]
rs2273773 1.0 [16257164]
rs10997870 1.0 [16257164]
rs2234975 1.0 [16257164]
rs7896005 0.0056 [21972126]
rs7069102 0.84 [18765803]
rs10823112 0.44 [18765803]
rs1885472 0.71 [18765803]
rs3758391 0.026 [20633545]
rs4746720 0.022 [20633545]
rs3758391 0.026 [20633545]
rs7896005 0.003 [21972126]
rs12778366 0.025 [23505545]
rs4746720 0.0001 [23450480]
rs3758391 1.0 [23450480]
rs3740051 1.0 [23450480]
rs2273773 1.0 [23450480]
Classification:
Longevity-Associated
No Age Effect
Type:
Gene
Protein coding
References:
16257164: Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity.
21972126: Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.
18765803: FOXO3A genotype is strongly associated with human longevity.
20633545: SIRT1 variants are associated with aging in a healthy Han Chinese population.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
SIRT1
(9606)
SIRT1
(9615)
SIRT1
(9913)
Sirt1
(10090)
Sirt1
(10116)
SIRT1
(9031)
sirt1
(7955)
Sir2
(7227)
sir-2.1
(6239)
Orthologs
SIR2
(4932)
HST1
(4932)
sir-2.1
(6239)
Sir2
(7227)
SIR2
(4932)
HST1
(4932)
sir-2.1
(6239)
Sir2
(7227)
SIR2
(4932)
Inparanoids
ENSP00000212015 (9606)
ENSMUSP00000112595 (10090)
ENSRNOP00000000427 (10116)
ENSMMUP00000035809 (9544)
ENSP00000212015 (9606)
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