Polymorphism: rs7896005
rs7896005 ( SNPedia | 23andMe )

Location: 10q21.3

Factor:
- Symbol: SIRT1
- Name: sirtuin 1
- Entrez ID: 23411
- Ensembl ID: ENSG00000096717

Factors:
  • SIRT1 sirtuin 1 ( 23411 / ENSG00000096717 )

  • Ethnicity: Caucasian
    Age of cases: Range: 90-103
    Shorter lived allele: A

    Statistics
    - Number of cases/controls: 224 vs 293 (initial) | 170 vs 220 (replication)
    - p-value: 0.0056 [0.0056]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology:

    Reference:
    21972126: Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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