Polymorphism: rs3758391
rs3758391 ( SNPedia | 23andMe )

Location: 10q21.3

Factor:
- Symbol: SIRT1
- Name: sirtuin 1
- Entrez ID: 23411
- Ensembl ID: ENSG00000096717

Factors:
  • SIRT1 sirtuin 1 ( 23411 / ENSG00000096717 )


  • Description:

    3 groups: centenarians, lon-lived, and controls. "These findings... suggest that there is no noteworthy influence of SIRT1 sequence variation on exceptional human longevity"

    Ethnicity: German
    Age of cases: Mean age 101

    Statistics
    - Number of cases/controls: 386 vs 640 vs 547 (initial)
    - p-value: 1.0 [1]
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: Taqman Allelic Discrimination

    Reference:
    16257164: Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity.

    Choice: Curate_Johnny
    Created: July 1, 2013, 10:03 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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