Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2802288 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs3772190 TERC — 0.006 1013 total — Danish — A G Candidate Region/Gene 22136229
    rs2075650 TOMM40 1.43 0.006 597 vs 1275 418 vs 450 Sichuan 90+ — — Candidate Region/Gene 24924924
    rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
    rs768023 FOXO3 1.27 0.007 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs422858 AGTR1 3.57 0.007 173 vs 376 — Italian 99-106 (mean 100.9±1.7) AG CC Candidate Region/Gene 22569962
    rs275653 AGTR1 3.57 0.007 173 vs 376 598 vs 422 Italian 99-106 (mean 100.9±1.7) A G Candidate Region/Gene 22569962
    rs1805081 NPC1 — 0.007 152 vs 120 — Polish >100 T C Candidate Region/Gene 18834923
    rs1799945 HFE — 0.008 57 vs 60 — Italian 100-105 — — Candidate Region/Gene 12714263
    rs699947 VEGFA 1.43 0.008 166 vs 324 — Italian 85-99 (mean 89.8±2.8) C A Candidate Region/Gene 17574707
    rs800140 TSPAN32 — 0.0081 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    rs1008438 HSPA1A — 0.009 894 total — Italian 18-109 A C Candidate Region/Gene 16896546
    rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
    rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
    rs2227956 HSPA1L — 0.01 191 vs 53 — Chinese >90 TC TT/CC Candidate Region/Gene 19840767
    rs12050077 TSHR 1.32 0.01 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs1800795 IL6 — 0.01 1710 total — Danish 47-100 C G Candidate Region/Gene 15130757
    rs2802290 FOXO3 1.26 0.01 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs4930001 DEAF1 — 0.010851 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    −1190G/A VEGFA 1.39 0.014 166 vs 324 — Italian 85-99 (mean 89.8±2.8) G A Candidate Region/Gene 17574707
    rs1042718 ADRB2 1.27 0.014 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 C A Candidate Region/Gene 23020224
    rs915179 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
    rs508641 LMNA — 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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