Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4537545 IL6R 3e-18 308 American, European, Ashkenazi Jewish 75.7 Candidate Region/Gene 19249341
    HRAS1 LASS1 (CGT) APOE 1.06e-09 68 vs 68 American Candidate Region/Gene 20569235
    E2 / E3 / E4 APOE 1.2e-08 560 vs 560 French centenarians 100th year or beyond, mean age 103.1 E4 Candidate Region/Gene 11280044
    DRD4 7R allele DRD4 3.5e-08 310 vs 2909 European mean age 95.2 years Candidate Region/Gene 23283341
    AAT M/Z/S AAT 0.18 1e-07 143 vs 255 vs 127 Italian Centenarians M, S Z Candidate Region/Gene 17048073
    HRAS1 LASS1 (CGT) APOE 6.91e-07 204 vs 251 American Candidate Region/Gene 20569235
    HFE C282Y HFE 7.2e-07 35 vs 106 91-105 (< 50 versus >90) C Y Candidate Region/Gene 11857056
    HRAS1 LASS1 (CGT) APOE 1e-06 79 vs 88 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 9e-06 19 vs 73 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 1e-05 128 vs 115 Georgian Candidate Region/Gene 20569235
    rs507879 CASP5 1.4e-05 510 vs 549 Russian 75–103 AG AA, GG Candidate Region/Gene 20434535
    rs4946936 FOXO3 1.40 1.8e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 T C Candidate Region/Gene 19793722
    rs1042718-rs1042719 ADRB2 0.63 1.86e-05 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G-C A-C Candidate Region/Gene 23020224
    rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 GTCT Candidate Region/Gene 22340368
    rs2802292 FOXO3 1.36 2.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 G T Candidate Region/Gene 19793722
    HRAS1 LASS1 (CCT) APOE 4.1e-05 147 vs 188 Georgian Candidate Region/Gene 20569235
    rs2755213 FOXO1 0.75 7.4e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
    HRAS1 LASS1 (CGT) APOE 7.8e-05 147 vs 188 Georgian Candidate Region/Gene 20569235
    rs2253310 FOXO3 1.35 7.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C G Candidate Region/Gene 19793722
    VNTR in intron 5 (DeltaEF1 site) SIRT3 8e-05 242 vs 703 Italian Median age 102 2b Candidate Region/Gene 15676284
    HRAS1 LASS1 (CCT) APOE 9.5e-05 204 vs 251 American Candidate Region/Gene 20569235
    rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish 100+ A Candidate Region/Gene 16602826
    AAT M/Z/S AAT 0.21 0.0001 143 vs 255 Minimum age 99 M, S Candidate Region/Gene 17048073
    rs12050077 TSHR 1.68 0.0001 232 vs 163 Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs1207362 KL 0.63 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
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    • 25 of 784 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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