Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs5491 ICAM1 5e-66 5036 American 28-70 TT, AT AA Genome-Wide Association Study 22174011
    rs9330200 TUBB4B 6e-53 5036 American 28-70 AA, AT TT Genome-Wide Association Study 22174011
    rs2292664 RIMBP2 1.4e-37 5036 American 28-70 CC, CG GG Genome-Wide Association Study 22174011
    rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
    rs2075650 APOE 0.71 3.39e-17 403 vs 1670 4149 vs 7582 Dutch mean 94 e4 Genome-Wide Association Study 21418511
    rs2075650 APOE 0.53 4.44e-16 2202 vs 2164 Caucasian 100 Meta-Analysis 24244950
    rs2149954 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ GWAS 24688116
    rs1528753 8.1e-08 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs4420638 APOE 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) Caucasian, European 90 Genome-Wide Association Study 23286790
    rs3129046 0.66 2.21e-07 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
    rs1610742 0.66 3.02e-07 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
    rs970048 Intergenic 1.77 7.17e-07 3746 vs 5912 Dutch Mean age 94 G Genome-Wide Association Study 21418511
    rs10493513 1.5e-06 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs1610601 0.68 1.98e-06 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
    rs2338013 0.67 2.07e-06 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
    rs4574762 0.19 2.29e-06 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs2371208 2.6e-06 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10493514 2.8e-06 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs6504441 PRKCA 0.60 2.87e-06 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs987839 SLCO1B1 3.19e-06 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs12413082 MSRB2 0.53 3.33e-06 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs17205854 3.74e-06 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs17811551 ADAMTS6 3.74e-06 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs1633063 0.68 3.82e-06 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
    rs3129063 0.67 4.33e-06 763 vs 1085 754 vs 850 German Mean age 99.7 Genome-Wide Association Study 21740922
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    • 25 of 572 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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