Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs9557276 CLYBL 1.33 4.6512e-05 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs2755213 FOXO1 0.75 7.4e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
    rs285097 RNF113B 0.47 7.76e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs9315385 DCAMKL1 1.74 8.13e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs1207362 KL 0.63 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
    rs1207362 KL 0.63 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 A — Candidate Region/Gene 22406557
    rs17702471 GPC6 1.16 0.000147857 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1805097 IRS2 2.03 0.0003 144 vs 418 — Italian 85-100 years old non-AA AA Candidate Region/Gene 19887537
    rs7319813 PIG38 1.39 0.000391694 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs7318601 PIG38 1.44 0.000508958 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs9530108 NBEA 1.26 0.00112398 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs9517320 STK24 — 0.00204 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
    −438 G/A TAFI 0.53 0.003 2224 — American, Caucasian 65+ G (men) — Candidate Region/Gene 15939070
    KL-VS KLOTHO 5.88 0.004 216 vs 309 — Ashkenazi Jewish 95 years and over homozygous — Candidate Region/Gene 15677572
    rs2755209 FOXO1 0.80 0.0046 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
    rs9536314 KL — 0.007 216 vs 309 — Ashkenazi Jewish >95 — TG (genotype) Candidate Region/Gene 15677572
    rs4148544 ABCC4 — 0.00977 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs201058276 F7 0.68 0.01 187 vs 201 — Danish centenarians R — Candidate Region/Gene 11602206
    323ins10 F7 0.69 0.01 187 vs 201 — Danish centenarians 323P0 — Candidate Region/Gene 11602206
    rs1805097 IRS2 2.07 0.04 144 vs 418 — Caucasian 85 to 104, mean age = 96 ± 4 C — Candidate Region/Gene 19887537
    R353Q F7 — 0.045 224 vs 441 — Ashkenazi Jewish 75 A G Candidate Region/Gene 15621215
    rs2721044 FOXO1 0.90 0.097 1447 vs 1029 (German) 166 vs 216 (Italian) German — — — Candidate Region/Gene 21388494
    rs2701859 FOXO1 0.90 0.117 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs2701880 FOXO1 0.83 0.12 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
    rs2721047 FOXO1A 0.98 0.177 1447 vs 1029 (initial) 166 vs 216 (Italian) (replication) German Mean age 98.8 — — Candidate Region/Gene 21388494
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    • 25 of 51 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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