Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (153)   No Age Effect (209)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP « 
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs7843014 — 0.37 0.001 175 vs 355 — Spanish 100-111 A C Candidate Region/Gene 24930376
    rs7460 PTK2 0.40 0.001 175 vs 355 — Spanish 100-111 A T Candidate Region/Gene 24930376
    rs2075650 TOMM40 0.70 0.002 2307 vs 764 — American, Danish Mean age 60.2 G A Candidate Region/Gene 23040522
    rs4073591 DEAF1 — 0.002618 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs1937 TFAM — 0.003 107 vs 284 — Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
    rs28359172 MT-ND5 0.30 0.003 98 vs 117 — Chinese 90–100 G — Candidate Region/Gene 18759861
    rs2291727 ADCY6 — 0.003 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
    rs1764391 GJA4 — 0.0035 56 vs 196 (males) — Italian >99 — CC Candidate Region/Gene 16970956
    rs13320360 MLH1 3.13 0.0036 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A — Candidate Region/Gene 22406557
    rs189037 (genotype) ATM — 0.004 875 (280 m, 595 f) vs 886 (491 m, 395 f) — Chinese Mean age 94,6, healthy — CT (Article); GA (ENSEMBL) Candidate Region/Gene 20816691
    rs4073590 DEAF1 — 0.004259 1600 samples (cases and controls combined) — German, Italian — — — Candidate Region/Gene 19367319
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 A — Candidate Region/Gene 22406557
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs1042522 TP53 0.88 0.005 9219 participants (Copenhagen City Heart Study) — Danish Range: 20-95 G — Candidate Region/Gene 18256523
    rs7762395 FOXO3 1.38 0.005 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A — Candidate Region/Gene 22406557
    rs429358, rs7412 APOE 0.75 0.005 2307 vs 764 — American, Danish Mean age 60.2 e4 e2 Candidate Region/Gene 23040522
    rs1061170 CFH 1.78 0.005 491 with follow-up during 4 years — Finn >90 — TT Candidate Region/Gene 19000922
    rs3211994 NTLH1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs3211994 NTHL1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) G — Candidate Region/Gene 22406557
    rs73598374 ADA 0.32 0.0056 97 vs 261 — Italian >88 G*/G* A*+ Candidate Region/Gene 21865054
    rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young — Italian 91+, 73-91 P — Candidate Region/Gene 23125046
    rs1800795 IL6 — 0.006 244 vs 309 138 vs 98 Italian 85+ CC (genotype) — Candidate Region/Gene 19377912
    rs6911407 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years — — Candidate Region/Gene 19196970

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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