| Microarray Game | 3 | 3 | Shytikov; Wuttke; Tang | There are many possibilities to analyze molecular Signatures. They can be compared to each other, meta-signature via Meta-Analysis can be derived, functional enriched terms can be assessed as well as Lifespan Factors identified.
It is possible to ... |
| Pentose Phosphate Pathway | 2 | 3 | Magalhaes; Wuttke; Tang | The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
... |
| miRNAs Control Aging | 3 | 8 | Schaum; Yivanoudi; Keller; Pate; Wuttke; Kumar; Conley; Swanson |
:Abstract: Gene silencing via RNA interference is mediated by microRNAs which are major controller of developmental processes and its plasticity conferred by diet. The function of specific miRNAs is going beyond the developmental period and extends... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
| Age In Vivo | 2 | 7 | Kulaga; Wuttke; AgeVivo; Logic; Mind; cryonicsculture; Horusavatar | *in vivo* (Latin for ``within living``) is experimentations that **utilizes whole living organisms**.
Age *in vivo* is ``do it yourself`` **Biology on Aging**. The goal is to bring in more people interested in Aging. Hence, it is primarily of prom... |
| Graph Visualization | 3 | 7 | Stambler; Kulaga; Wuttke; Nishry; Mind; Atraylen; Horusavatar | **Data on Aging** need to be **visualized** with an ``interactive`` and ``intuitive interface`` that enables ``collaborative reverse-engineering`` of the Aging process. It shall be a popular and interactive way of to convey a basic understanding of t... |
| Circadian Rhythm | 2 | 4 | Kapahi; Magalhaes; Wuttke; Katewa | Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker [23223368].
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
| Tissue-Specific DR-Effects | 2 | 4 | Kapahi; Magalhaes; Wuttke; Li |
:Abstract: A restricted diet without malnutrition highly effectively counteracts ageing in several species and extends robustly their lifespan. How lifespan is extended remains enigmatic. We utilized tissue-specific gene expression data in *Droso... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
| Age In Vivo | 2 | 7 | Kulaga; Wuttke; AgeVivo; Logic; Mind; cryonicsculture; Horusavatar | *in vivo* (Latin for ``within living``) is experimentations that **utilizes whole living organisms**.
Age *in vivo* is ``do it yourself`` **Biology on Aging**. The goal is to bring in more people interested in Aging. Hence, it is primarily of prom... |
| Human Experimental Aging Biology | 2 | 3 | Debonneuil; Wuttke; Watson | The system of clinical trials in Western countries has been bogged down by high costs, red tape, and governmental restrictions to the point that within 10 years the engine of innovation in biotechnology will die [22378269].
In order to prevent thi... |
| Continuous Longevity Meeting | 3 | 4 | Debonneuil; Wuttke; Singh; Maidano | The **Worldwide Continuous Longevity Meeting** is a continuous ``discussion channel`` where anyone can decide to launch global collaborative presentations. The inventor **Edouard Debonneuil** proposed to incorporate it as an organ of the ``Internatio... |
| Collaborative Knowledge-Management | 1 | 2 | Kulaga; Wuttke | We will establish **new kind of collaboration models** between people (including Researches) and in **Graph representation of knowledge**.
``Collaboration and knowledge-management websystems`` are the clue that **increases collective intelligence*... |
| Information Theory | 2 | 3 | Stambler; Wuttke; Blokh | Information theory is a field of applied mathematics, engineering and computer science that measures information.
It originates from the finding of the fundamental limits on signal processing operations, such as compressing data, and on reliable s... |
| Encouraging Initiative | 1 | 2 | Wuttke; Coernette | A merit earning system build on top of the Achievements, that gives Researchers, Developers and Artists as well as other people the recognition and respect for their contribution and work need to be established. Such a system that awards merit for go... |
| Graph Visualization | 3 | 7 | Stambler; Kulaga; Wuttke; Nishry; Mind; Atraylen; Horusavatar | **Data on Aging** need to be **visualized** with an ``interactive`` and ``intuitive interface`` that enables ``collaborative reverse-engineering`` of the Aging process. It shall be a popular and interactive way of to convey a basic understanding of t... |
| Pentose Phosphate Pathway | 2 | 3 | Magalhaes; Wuttke; Tang | The pentose phosphate pathway chiefly generates reduction equivalents in the form of NADPH:
3 G6P + 6 NADPH+ + 3 H2O = 6 NADPH + 6 H+ + 3 CO2 + 2 F6P + GAP
6 equivalents of NADPH is quite a lot for just three sugars. NADPH might scavenge ROS.
... |
| in situ Regeneration | 1 | 2 | Wuttke; Zamani |
:Abstract: As we are young everything regenerates perfectly. In fact, our body harbors the plan to reconstruct itself from scratch which is localized in the nucleus of each of our body cells. However, as we grow up our regenerative capacities decre... |
| Circadian Rhythm | 2 | 4 | Kapahi; Magalhaes; Wuttke; Katewa | Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker [23223368].
Middle aged flies exhibit reduced activity level in comparison with young controls. ... |
| Denigma | 5 | 9 | Fuellen; Magalhaes; Debonneuil; Kulaga; Wuttke; Adams; Borisoglebsky; Fortney; Hall | Denigma is the digital Enigma destined to decipher biological phenomena. All information of an organism is encoded in its genome and can be decrypted via the combined effort of humans and machines. For this, Denigma was build for.
Specifically, Deni... |
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