Collaboration Circadian Rhythm

Involved Labs/Organisations (2): Integrative Genomics of Ageing Group, Kapahi Lab
Participating Members (4): Pankaj Kapahi, Joao Pedro de Magalhaes, Daniel Wuttke, Subhash Katewa

Most animals have rest/activity/rhythms that are powered by an endogenous timing mechanism, the circadian system. With aging the rhythm becomes weaker [23223368].

Middle aged flies exhibit reduced activity level in comparison with young controls. The free-running period significantly lengthened under constant darkness and the rhythm strength diminishes [23223368].

The daily rhythm is brain controlled, but its mechanism is encoded by cell-autonomous circadian clock functioning in nearly every body cell [21482780].

The molecular machinery of peripheral circadian clocks appears not to change, but some age-related circadian dysfunction are of hormonal origin. Fibroblast period length, amplitude, and phase are identical in those derived from young and old humans, suggesting that the basic clock properties of peripheral cells do not change during aging. However in the presence of the serum from old donors shortens the period length and advances the phase of cellular circadian rhythms compared to treatment with serum from young individuals, indicating that circulating Factors alter human chronotype. This effect is caused by a thermolabil Factor present in serum of older individuals [21482780].

The cytoskeleton changes greatly following a Circadian Rhythm. The liver cells of rodents change their structure during the day, with an average size increase about 50% at the end of the night. [23374345] o


  • 18846204 Analysis of gene regulatory networks in the mammalian circadian rhythm.
  • 23374345 Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity.
  • 23513468 The expression of Per1 and Aa-nat genes in the pineal gland of postnatal rats.
  • 20228939 Effect of feeding regimens on circadian rhythms: implications for aging and longevity.
  • 21376793 Long-lived mice exhibit 24 h locomotor circadian rhythms at young and old age.
  • 22593546 Timed high-fat diet resets circadian metabolism and prevents obesity.
  • 23050095 Meal frequency patterns determine the phase of mouse peripheral circadian clocks.
  • 22395806 The circadian clock and pathology of the ageing brain.
  • 21454295 Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta.
  • 12149444 Effects of aging on central and peripheral mammalian clocks.
  • 22268765 Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations.
  • 22705307 Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components.
  • 22672634 Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways.
  • 19854863 Metabolism and circadian rhythms--implications for obesity.

  • Update

    Comment on This Data Unit