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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
HLA-A phenotype HLA-A 1.95 0.002 201 vs 211 Chinese 22 centenarians + 179 nonagenarians (mean age 93 ±1.04) A9 A30 Candidate Region/Gene 9147371
HLA-C phenotype HLA-C 0.49 0.02 201 vs 211 Chinese >93 Cw3, Cw6. Cw7 Candidate Region/Gene 9147371
5-HTTLPR SLC6A4 0.03 15 male, 53 female centenarians (cases) Australian, Caucasian 101.0 ± 0.2 L/L (only for males) Candidate Region/Gene 22985157
  • 3 variants