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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
Irish «
Italian (2)
Study type:
+
-
Candidate Region/Gene «
Variant type:
+
-
SNP (4)
Deletion (1)
Variant effect:
+
-
Longevity‑Associated (3)
No Age Effect (7)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
rs429358, rs7412
APOE
0.43
0.0006
114 vs 2071
—
Irish
>90
e4
e2
Candidate Region/Gene
11470126
192 (Q/R)
PON1
1.30
0.007
308 vs 579 Italian, 296 vs 296 Irish
—
Irish
,
Italian
Italian 100.8 years, Irish 89.8 years
Q
—
Candidate Region/Gene
15050299
192
PON1
1.26
0.007
Italian: 308 vs 579; Northern Irish: 296 vs 296
—
Irish
Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7
Q
—
Candidate Region/Gene
15050299
2437 T>C
HSPA1L
—
0.01
129 vs 100
—
Irish
80–97
2437C
—
Candidate Region/Gene
12742533
KIR2DS3
KIR2DS3
—
0.02
93 vs 100
89 vs 89
Irish
80-97
—
—
Candidate Region/Gene
15288696
KIR2DL5
KIR2DL5
—
0.03
93 vs 100
89 vs 89
Irish
80-97
—
—
Candidate Region/Gene
15288696
KIR2DS3 haplotypes
KIR2DS3
—
0.05
100 vs 100
—
Irish
Age range: 65-99
—
—
Candidate Region/Gene
21299522
rs662
PON1
1.06
0.086
5086 vs 4269
—
Irish
>/=80
—
—
Candidate Region/Gene
20362697
rs662
PON1
1.06
0.33
—
—
Irish
>/=80
—
—
Candidate Region/Gene
20362697
55 (L/M)
PON1
0.94
0.44
308 vs 579 Italian, 296 vs 296 Irish
—
Irish
,
Italian
Italian 100.8 years, Irish 89.8 years
—
—
Candidate Region/Gene
15050299
rs662
PON1
1.03
0.55
—
—
Irish
>/=100
—
—
Candidate Region/Gene
20362697
(HLA)-A1, B8, DR3
—
—
1.0
93 vs 100
—
Irish
80-97 years
—
—
Candidate Region/Gene
12714268
rs1800629
TNF
—
1.0
93 vs 100
—
Irish
80-97 years
—
—
Candidate Region/Gene
12714268
rs909253
TNF
—
1.0
93 vs 100
—
Irish
80-97 years
—
—
Candidate Region/Gene
12714268
rs72533289
KIR2DS4
—
1.0
180 vs 180
—
Irish
Mean age 89
—
—
Candidate Region/Gene
15130674
15 variants
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