Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4537545 IL6R — 3e-18 308 — American, European, Ashkenazi Jewish 75.7 — — Candidate Region/Gene 19249341
HRAS1 LASS1 (CGT) APOE — 6.91e-07 204 vs 251 — American — — — Candidate Region/Gene 20569235
HRAS1 LASS1 (CGT) APOE — 1e-06 79 vs 88 — American — — — Candidate Region/Gene 20569235
HRAS1 LASS1 (CGT) APOE — 9e-06 19 vs 73 — Georgian — — — Candidate Region/Gene 20569235
HRAS1 LASS1 (CCT) APOE — 1e-05 128 vs 115 — Georgian — — — Candidate Region/Gene 20569235
HRAS1 LASS1 (CCT) APOE — 4.1e-05 147 vs 188 — Georgian — — — Candidate Region/Gene 20569235
HRAS1 LASS1 (CGT) APOE — 7.8e-05 147 vs 188 — Georgian — — — Candidate Region/Gene 20569235
HRAS1 LASS1 (CCT) APOE — 9.5e-05 204 vs 251 — American — — — Candidate Region/Gene 20569235
XRCC3 intron 3 STR — — 0.0005 430 (case) vs 290 — British Mean age 70 15 13 Candidate Region/Gene 16518718
XRCC5 120 bp 5` (GAPyA)n STR — — 0.0005 430 (case) vs 290 — British Mean 70 16+2 15 Candidate Region/Gene 16518718
SI000565Q APOB — 0.001 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 — LL Candidate Region/Gene 17393087
rs11279109 - APOB XbaI APOB — 0.001 191 (case) vs 53 (initial) — Chinese > 90 baseline, Mean age 97 +/- 3 — D - X+ Candidate Region/Gene 17393087
HRAS1 LASS1 (CCT) APOE — 0.00197 125 vs 163 — American — — — Candidate Region/Gene 20569235
−438 G/A TAFI 0.53 0.003 2224 — American, Caucasian 65+ G (men) — Candidate Region/Gene 15939070
rs189037 ATM — 0.004 875 vs 886 — Chinese mean 94.6 — CT Candidate Region/Gene 20816691
APOB XbaI − SI000565Q APOB — 0.006 191 (case) vs 53 (initial) — Chinese > 90 baseline, Mean age 97 +/- 3 X+ - Short X+ - Medium Candidate Region/Gene 17393087
rs11066301 PTPN11 — 0.0111 288 vs 554 — Calabrian 90+, median 92 — — Candidate Region/Gene 22576335
APOE polymorphism - HP1/2 common polymorphism APOE — 0.013 200 (cases) vs 539 (initial) — Italian >88 e4-H2 (haplotype) — Candidate Region/Gene 21703254
rs939915 SIRT3 — 0.0145 2461 samples (cases and controls combined) — Italian — — — Candidate Region/Gene 19367319
rs6589722 — — 0.015 209 vs 402 — Japanese 95+ — — Candidate Region/Gene 23770741
rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
V465A GABRR3 — 0.04 390 vs 410 — Ashkenazi Jewish Centenarians — — Candidate Region/Gene 23376243
VNTR DC-SIGNR — 0.041 361 vs 342 — Chinese >90 non-6/7 genotype 6/7 genotype Candidate Region/Gene 20003397
rs11279109 - APOB XbaI - SI000565Q APOB — 0.044 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
I carriers of ACE — — 0.045 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
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