Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

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    ‑ (19)   Candidate Region/Gene (382)   Meta‑Analysis (8)   Genome‑Wide Association Study (103)   Mitochondrial Haplogroup (27)  
  • Variant type: + -
    SNP (314)   Haplotype (43)   Other (1)   STR (7)   Deletion (1)  
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs11279109 - SI000565Q APOB — 0.05 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - S D - M Candidate Region/Gene 17393087
    5178 adenine/cytosine ND2 — 0.363 95 vs 298 — Chinese 76.2±5.0 C — Candidate Region/Gene 12384792
    rs9400239 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 C — Candidate Region/Gene 20849522
    rs1800802 MGP 0.77 0.132 137 vs 213 — Korean Mean age 90 C — Genome-Wide Association Study 19641380
    rs3764650 ABCA7 — 0.135 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs610932 MS4A6A — 0.176 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs3865444 CD33 — 0.442 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs1485780 CD2AP — 0.604 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs2805533 ADARB2 0.91 0.1904 877 vs 1808 Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. Northern European 96–119 (median: 103) AA/AG — — 20011587
    rs884949 ADARB2 1.19 0.0911 877 vs 1808 Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. Northern European 96–119 (median: 103) AA — — 20011587
    rs2387653 ADARB2 1.17 0.1053 877 vs 1808 Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. Northern European 96–119 (median: 103) AA — — 20011587
    rs9398172 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 A — Candidate Region/Gene 20849522
    rs2853826 MT-ND3 — 0.219 98 vs 117 — Chinese 90–100 A — Candidate Region/Gene 18759861
    rs744373 BIN1 — 0.689 1364 — American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
    rs11136000 CLU — 0.975 1364 — American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
    XRCC5 120 bp 5` (GAPyA)n STR — — 0.0005 430 (case) vs 290 — British Mean 70 16+2 15 Candidate Region/Gene 16518718
    XRCC3 intron 3 STR — — 0.0005 430 (case) vs 290 — British Mean age 70 15 13 Candidate Region/Gene 16518718
    rs479744 FOXO3 — 0.05 1089 vs 736 — Danish 92–93 (can't figure out using ensemble and NCBI) — Candidate Region/Gene 20849522
    rs2071065 TPI1 — 0.05 1422 vs 967 — German mean age: 98.8, age range: 95–110 (SNP is T/C) — Candidate Region/Gene 18510744
    rs1801274 FCGR2A — 0.05 408 vs 446 vs 454 — German 100–110/ mean101.3 (SNP is His/Arg) — Candidate Region/Gene 16893392
    rs2071069 TPI1 — 0.05 1422 vs 967 — German mean age: 98.8, age range: 95–110 (SNP is G/A) — Candidate Region/Gene 18510744
    rs2866164 MTTP — 1.0 1651 vs 575 — Danish 92-93 — — Candidate Region/Gene 16015282
    APOC3-SstI-RFLP (3'UTR, 3238 nt) APOC3 — 0.05 229 vs 571 — Calabrian 81–109 (median 101) — — Candidate Region/Gene 12556235
    rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
    length (STR polymorphism) TH — 1.0 196 vs 358 471 vs 462 German (in replication) 96-110 years — — Candidate Region/Gene 21407269

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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