Authors: Yao YG; Kong QP; Zhang YP
Abstract: Previous studies have shown that mitochondrial DNA (mtDNA) 5178 adenine/cytosine (5178A) polymorphism, which is one of the haplogroup-specific mutations for mtDNA haplogroup D, was apparently associated with aging and longevity in humans. We genotyped the 5178A in 293 samples representing three age groups (Old, n=95; Young, n=103; and Infant, n=95) from Yunnan Province, China. The distribution frequency of the 5178A in the Old samples (16.84%) is slightly higher than in those of the Young (13.59%) and Infant (15.79%), but the frequency difference between the age groups is far from being statistically significant ( P>0.05). Our results fail to support the suggestion of association between mtDNA 5178A (or haplogroup D) and longevity.
Keywords: Adult; Age Distribution; Aged; Aged, 80 and over; DNA, Mitochondrial/*genetics; Humans; Infant; Longevity/*genetics; *Polymorphism, Genetic|
Journal: Human genetics Volume: 111 Issue: 4-5 Pages: 462-3 Date: Oct. 18, 2002 PMID: 12384792 |
Yao YG, Kong QP, Zhang YP (2002) Mitochondrial DNA 5178A polymorphism and longevity. Human genetics 111: 462-3.
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