| YPT7 deletion | YPT7 deletion decreases replicative lifespan by 15% in the alpha strain [18340043]. Deletion of YPT7 cancels out replicative lifespan extension of 0.5% glucose restriction and results under DR also into a shorter replicative lifespan than under AL [18690010]. | Yeast | -15 | — | — |
| YHC3 deletion | YHC3 deletion decreases 10-20% shortened lifespan [16435200]. | Yeast | -10 to -20 | — | — |
| YGL235W deletion | YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. | Yeast | +20 | — | — |
| YDL180W deletion | YDL180W deletion impairs DR-mediated replicative lifespan extension, but does not change lifespan on AL significantly [22912585]. | Yeast | +5 | — | -6 |
| yata mutation | yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 [19209226]. | Fly | — | — | -68 |
| VPS36 deletion | VPS36 deletion mutant had a chronological lifespan as long as wild type BY4741. Thus, Vps36 is not necessary for the starvation/extreme DR-dependent lifespan extension [20657825]. | Yeast | — | — | — |
| VPS30 deletion | VPS30 deletion prevents chronological lifespan extension induced by amino-acid DR [20421943]. | Yeast | — | — | — |
| VPS20 deletion | VPS20 deletion decreases mean and maximum replicative lifespan by 16% and 19%, respectively, and additionally cancels out the DR-induced replicative lifespan extension [22912585]. | Yeast | -16 | — | -19 |
| VMA2 deletion | VMA2 deletion mutants have a reduced ΔΨ and mitochondrial morphology similar to aged cells. The restoration of the vacuolar acidity in daughter cells requires V-ATPase activity as it is eliminated in VMA2 deletion mutant cells [23172144]. VMA2 deletion mutation decreases the mean replicative lifespan by 80% in the alpha strain [18340043]. Deletion of VMA2 decreases mean, median and maximum replicative lifespan by 84%, 84% and 70%, respectively. DR (0.5% glucose restriction) does not extend the replicative lifespan of VMA2 and shortens it even more [23172144]. | Yeast | -80 to -83.9 | -84.1 | -70.0 |
| VAM7 deletion | VAM7 deletion decreases replicative lifespan under AL and blocked DR-mediated lifespan extension. Replicative lifespan decreases by 70% on DR in VAM7 deletion mutant [18690010]. | Yeast | — | — | — |
| VAC14 deletion | VAC14 mutants have a single vacuole and shortened lifespan on normal media [16293764]. | Yeast | — | — | — |
| ARO7 deletion | Under starvation/extreme DR deletion of ARO7 increases mean chronological lifespan and confers higher resistance to heat-shock, but made cell more sensitive to acetic acid and leads to growth defects. In W303-1A background ARO7 deletion causes an even more severe growth defect and mutants are short-lived [20657825]. | Yeast | — | — | — |
| VPS27 deletion | Under starvation conditions VPS27 deletion mutants have a dramatically reduced lifespan [20953148]. | Yeast | — | — | — |
| ATG16 deletion | Under AL atg16 mutation shortens chronological, but not replicative lifespan. 0.5% glucose DR extends chronological lifespan of atg16 mutants, but amino-acid DR does not extend the short chronological lifespan of atg16 mutants (similar to several other autophagy mutants). ADE4 deletion in atg16 mutants results only in a partial extension of chronological lifespan by 0.5% glucose DR. The long chronological lifespan of tor1 mutants requires ATG16 [20421943]. | Yeast | — | — | — |
| unc-76 mutation | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Worm | +50 | — | — |
| unc-51 mutation | unc-51(e369) mutation reduces mean but extends maximum lifespan. unc-51(e369) mutation reduces lifespan of eat-2(ad1116) mutants to that of wild-type [18219227]. | Worm | — | — | — |
| unc-46 mutation | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-35 mutation | unc-35(e259) has no effect on male or hermaphrodite lifespan [10747056].
unc-35 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-32 mutation | unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].
unc-31 mutants are uncoordinated [4366476]. | Worm | +170 | — | — |
| UCHL1 mutation | UCHL1 is assoicated with Parkinson's disease [9774100]. UCHL1 belongs to a family of de-ubiquitinating enzymes responsible for the hydrolysis of bonds between ubiquitin molecules and small adducts [11084366]. Decreased activity due to mutation may result in decreased labeling of abnormal proteins for clearance. | Human | — | — | — |
| Dominant-negative S6k | Ubiquitous overexpression of a dominant-negative form of S6k (alias dS6K) increases mean lifespan by 22%. Overexpression of a dominant-negative form of S6k protects mutants from deleterious effects of rich food, as if mimicking the effect of DR [15186745]. | Fly | +22 | — | — |
| rut mutation | Two rutabaga mutants, rut1 and rut2080, have significantly shortened lifespans [17369827]. | Fly | — | — | — |
| Trx-2 mutation | Trx-2 mutants have a 25% reduction in maximum lifespan and exhibit lower tolerance to oxidative stress while animals carrying multiple copies of Trx-2 exhibit higher tolerance [17567437]. | Fly | — | — | -25 |
| TRM9 deletion | TRM9 deletion almost triples mean chronological lifespan under starvation/extreme DR, increases heat resistance, but reduces resistance to acetic acid. Similar effect were present in the BY746 background in SDC medium [20657825]. | Yeast | — | — | — |
| CYR1 transposition | Transposon-mutagenized CYR1 increases resistance to oxidants and extends chronological lifespan by up to 90%. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 are required for this lifespan extension [11292860]. | Yeast | +300 | — | — |
GenAge
GenDR
