Interventions

  • name effect species mean median maximum
    zyg-11 RNAi zyg-11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    ZC395.10 RNAi ZC395.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    YPT7 deletion YPT7 deletion decreases replicative lifespan by 15% in the alpha strain [18340043]. Deletion of YPT7 cancels out replicative lifespan extension of 0.5% glucose restriction and results under DR also into a shorter replicative lifespan than under AL [18690010]. Yeast -15
    YHC3 deletion YHC3 deletion decreases 10-20% shortened lifespan [16435200]. Yeast -10 to -20
    YGL235W deletion YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. Yeast +20
    YDL180W deletion YDL180W deletion impairs DR-mediated replicative lifespan extension, but does not change lifespan on AL significantly [22912585]. Yeast +5 -6
    YDC1 overexpression YDC1 overexpression decreases chronological lifespan by 40% [19059240]. Yeast -40
    yata mutation yata mutation shortens the maximum lifespan by 68% and results in progressive deterioration of the nervous tissues and aberrant accumulation of Sec23 [19209226]. Fly -68
    Y41E3.11 RNAi Y41E3.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    xrn-1 RNAi xrn-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    wwp-1 overexpression wwp-1 overexpression extends lifespan by up to 20%. RNAi reduction of pha-4, but not of daf-16 suppresses increased longevity by wwp-1 overexpression [19553937]. Worm +20
    Plasmodien infection With plasmodien infected mosquitous have a reduced fertility but life much longer [http://www.wissenschaft.de/wissenschaft/news/315905.html; http://rspb.royalsocietypublishing.org/content/early/2012/07/30/rspb.2012.1394].
    nhr-62 Overexpression Wild-type (N2) worms with extrachromosomal array dhEx627 (carrying a wild-type nhr-62) exhibit a significant increase in lifespan compared to wild-type (p<0.001) [Heestand et al. 2013]. Worm
    Whole-body Sirt1 deletion in the adulthood Whole-body deletion of Sirt1 in the adulthood results in mice which are seemingly normal in every way. When mice were given low doses of resveratrol after Sirt1 was disabled, there were no discernible improvement in mitochondrial function or any paramenter, while mice with normal Sirt1 function given reservatrol showed dramatic increases in energy, mitochondrial biogenesis and function, AMPK activation and increased NAD+ levels in skeletal muscle. When mice lacking Sirt1 were given low doses of reserveratrol, AMPK was unaffected. When doses were significantly increased in these mice, AMPK was activated in a SIRT1-indepent manner, but still no benefit to mitochondrial function resulted [22560220]. Mouse
    LAG2 overexpression When LAG2 is overexpressed in SP1 strain, the mean and maximum replicative lifespan is extended by about 36% and 54%, respectively. Overexpression induced at generation 12 similarly increases replicative lifespan [8760941]. Yeast +36 +54
    wah-1 RNAi wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. Worm +7 to +8
    VPS36 deletion VPS36 deletion mutant had a chronological lifespan as long as wild type BY4741. Thus, Vps36 is not necessary for the starvation/extreme DR-dependent lifespan extension [20657825]. Yeast
    VPS30 deletion VPS30 deletion prevents chronological lifespan extension induced by amino-acid DR [20421943]. Yeast
    VPS20 deletion VPS20 deletion decreases mean and maximum replicative lifespan by 16% and 19%, respectively, and additionally cancels out the DR-induced replicative lifespan extension [22912585]. Yeast -16 -19
    VMA2 deletion VMA2 deletion mutants have a reduced ΔΨ and mitochondrial morphology similar to aged cells. The restoration of the vacuolar acidity in daughter cells requires V-ATPase activity as it is eliminated in VMA2 deletion mutant cells [23172144]. VMA2 deletion mutation decreases the mean replicative lifespan by 80% in the alpha strain [18340043]. Deletion of VMA2 decreases mean, median and maximum replicative lifespan by 84%, 84% and 70%, respectively. DR (0.5% glucose restriction) does not extend the replicative lifespan of VMA2 and shortens it even more [23172144]. Yeast -80 to -83.9 -84.1 -70.0
    vit-2 RNAi vit-2 RNA interference extends mean lifespan by 21-24% [12845331]. Worm +21 to +24
    vit-1 RNAi vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different [12845331]. Worm
    vig-1 RNAi vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    VAM7 deletion VAM7 deletion decreases replicative lifespan under AL and blocked DR-mediated lifespan extension. Replicative lifespan decreases by 70% on DR in VAM7 deletion mutant [18690010]. Yeast
    VAC14 deletion VAC14 mutants have a single vacuole and shortened lifespan on normal media [16293764]. Yeast
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    • 25 of 1570 interventions
    Interventions are an extension of GenAge and GenDR.