| zyg-11 RNAi | zyg-11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| ZC395.10 RNAi | ZC395.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| Y41E3.11 RNAi | Y41E3.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| xrn-1 RNAi | xrn-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| wah-1 RNAi | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Worm | +7 to +8 | — | — |
| vit-2 RNAi | vit-2 RNA interference extends mean lifespan by 21-24% [12845331]. | Worm | +21 to +24 | — | — |
| vit-1 RNAi | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different [12845331]. | Worm | — | — | — |
| vig-1 RNAi | vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| vab-1 RNAi | vab-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| l(3)neo18 RNAi | Under rich nutritional conditions lifespan of l(3)neo18 (alias CG9762) RNAi knockout animals is indistinguishable from wild-type, while upon DR, lifespan extension is diminished in males and females [19804760]. | Fly | — | — | — |
| CG11015 RNAi | Under rich nutritional conditions lifespan of CG11015 RNAi treated animals is indistinguishable from that of controls, while upon DR, lifespan extension is diminished in males and females [19804760]. | — | — | — | — |
| trap-4 RNAi | trap-4 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| SCH9 Transposition | Transposon-mediated mutagenesis of SCH9, which encodes for a serine threonine kinase homologous to Akt/PKB, increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30% [11292860]. | Yeast | +30 | — | — |
| Transient CDC7 inactivation | Transient inactivation of CDC7 results in a shortened replicative lifespan [2698814]. | Yeast | — | — | — |
| CDC6 mutation | The CDC6-1 conditional allele results in an approximately 20% increase in mean replicative life span. This allele is defective for replicative initiation form the rDNA ARS at 27 degree Celsius, resulting in a reduced rate of extrachromosomal rDNA circle accumulation [9428525]. The cdc6-1 allele results in genomic instability at the permissive temperature [8552037]. | Yeast | +20 | — | — |
| tba-5 RNAi | tba-5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| tag-341 RNAi | tag-341 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| tag-322 RNAi | tag-322 RNAi increases mean and maximum lifespan by 18 and 12%, respectively [19293945]. | Worm | +18 | — | +12 |
| T23D8.3 RNAi | T23D8.3 RNAi in the adulthood extends mean and maximum lifespan by 26% and 35, respectively [23144747]. | Worm | +25.7 | — | +34.7 |
| T08A11.2 RNAi | T08A11.2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| T04A8.11 RNAi | T04A8.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| synaptobrevin RNAi | synaptobrevin RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| Surf1 knockdown | Surf1 knockdown results in larval lethality. However, knockdown in the central nervous system (CNS) not only bypasses the larval lethality but it results in an increase in maximum lifespan of about 20-30% [16172499]. | Fly | — | — | +20 to +30 |
| sur-2 RNAi | sur-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| srh-20 RNAi | srh-20 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
GenAge
GenDR
