| CG32022 | — | CG32022 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG34243 | — | CG34243 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG34426 | — | CG34426 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG4726 | — | CG4726 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG4942 | — | CG4942 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG5194 | — | CG5194 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
| Fruit fly |
| CG6041 | — | CG6041 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG6048 | — | CG6048 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG6184 | — | CG6184 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG6195 | — | CG6195 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
| CG6511 | — | CG6511 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG7852 | — | CG7852 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head and abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
| mir-277 | — | Constitutive miR-277 expression shortens lifespan and synthetically lethal with reduced insulin signaling, indicating that metabolic control underlies this phenotype. Transgenic inhibition with a miRNA sponge construct also shortens lifespan [23669073].
miR-277 is downregulated during adult life [23669073].
mir-277 controls branched-chain amino acid catabolism and as a result it can modulate the activity of TOR kinase [23669073]. | Fruit fly |
| Sirt2 | — | Decreased expression of Sirt2 by RNA interference causes lethality during development. Silencing in neurons shortened mean lifespan by 20% [17159295]. | Fruit fly |
| Sirt6 | — | Decreased expression of Sirt6 by RNA interference causes lethality during development. Sirt6 silencing in neurons shortens mean lifespan by 20% [17159295]. | Fruit fly |
| Scgdelta | Sarcoglycan delta | Deletion of Scgdelta has detrimental effects on the flight muscles of adult animals and heart function. Median lifespan is reduced by 15-30% [17855453]. | Fruit fly |
| SNF4Agamma | SNF4/AMP-activated protein kinase gamma subunit | Deletion of SNF4Agamma from the first day of the imaginal stage shortens mean lifespan by 23% and causes morphological and behavioural features of premature aging [18219227]. | Fruit fly |
| esg | Escargot | Disruption of esg by insertion of the P{GT1} vector 300 bp downstream of its structural part increases male and female lifespan. Heterozygous esg and insc double mutants interact in the course of lifespan determination. The decrease of esg transcription is associated with lifespan increase in mutant esg and insc flies [22661237]. | Fruit fly |
| DLP | Daxx-like protein | DLP mutants have a 20% shorter mean lifespan and reduced female fertility [17933869]. | Fruit fly |
| Doc1 | — | Doc1 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705].
| Fruit fly |
| Doc3 | Dorsocross3 | Doc3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Gain-of-function mutation in Doc3 causes delay of age-related motor impairment [19481596].
| Fruit fly |
| dro2 | drosomycin-2 | dro2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
| dro4 | drosomycin-4 | dro4 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
| elav | embryonic lethal abnormal vision | elav mutation significantly decreases the lifespan. Median lifespan in males is 66% lower [20589912]. | Fruit fly |
| endoA | endophilin A | endoA exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
