Involvement of Drosophila Sir2-like genes in the regulation of life span.

Authors: Kusama S; Ueda R; Suda T; Nishihara S; Matsuura ET

Abstract: In Drosophila melanogaster, the Sir2 gene and four Sir2-like genes have been found to be homologous to yeast SIR2 genes. To examine whether the fly Sir2, CG5216, and two Sir2-like genes, CG5085 and CG6284, affect life span, we suppressed their expression using RNAi. Decreased expression of the Sir2 and Sir2-like genes in all cells caused lethality during development. Suppression of the Sir2 in neurons and ubiquitous silencing of the Sir2-like genes shortened life spans. The effects were severer at 28 degrees C than at 25 degrees C. These results suggest that Sir2-like genes as well as Sir2 are involved in the regulation of life span in Drosophila.

Keywords: Animals; Drosophila Proteins/*genetics; Drosophila melanogaster/*genetics/physiology; Histone Deacetylases/*genetics; Longevity/*genetics; Sirtuins/*genetics
Journal: Genes & genetic systems
Volume: 81
Issue: 5
Pages: 341-8
Date: Dec. 13, 2006
PMID: 17159295
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Citation:

Kusama S, Ueda R, Suda T, Nishihara S, Matsuura ET (2006) Involvement of Drosophila Sir2-like genes in the regulation of life span. Genes & genetic systems 81: 341-8.


Study Lifespan Factors:
  • Sir2
  • Sirt2
  • Sirt6


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