Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Fission yeast (1)   Budding yeast (11)   Nematode (6)   Fruit fly (8)   Human (1)   Cattle (1)   House mouse (3)  
  • Classifications: + -
    Negative Gerontogene «  Aging Associated (1)   Aging Differential (1)   Aging‑Suppressed (1)   Aging‑Suppressor (9)   Negative Aging‑Suppressor (8)   Positive Aging‑Suppressor (1)   Gerontogene (32)   Positive Gerontogene (10)   DR‑Induced (2)   DR‑Essential (5)  
  • Types: + -
    Gene (8)   Protein coding (6)   miRNA (2)  
    • symbol name observation species
    YDC1 Yeast DihydroCeramidase 1 Overexpression of YDC1 decreases chronological lifespan by 40% [19059240] Budding yeast
    Terf2 telomeric repeat binding factor 2 Overexpression results in signs of premature ageing. House mouse
    CLN3 CycLiN 3 Overexpression shortens chronological lifespan together with age-dependent increases in genome instability and apoptosis. While around 80% of wild-type cells are alive almost non CLN3 overexpressers are alive (under condition that avoids adaptive regrowth) [17710147]. Budding yeast
    tdp-1 TAR DNA-binding Protein homolog 1 tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. Nematode
    let-60 LEThal The let-60(n1046gf) activating mutation greatly reduces lifespan of wild-type, weakly suppresses constitutive dauer diapause in daf-2 and age-1 mutants and extends lifespan induced by mutation of daf-2 [16164423]. Nematode
    GH1 Growth hormone 1 Transgenic mice overexpressing bovine GH1 are bigger than controls and display early onset of pathological changes in the kidneys such glomerulosis and glomerulonephritis as well as signs of premature aging such as a shortened lifespan, increased astrogliosis, shortened reproductive lifepsan and early onset of age-related changes in cognitive function, hypothalamic neurotransmitter turnover, and plasma corticosterone levels [14583653]. Cattle
    S6k RPS6-p70-protein kinase Ubiquitous overexpression of a dominant-negative form of S6k (alias dS6K) increases mean lifespan by 22% and overexpression of a constitutively active form of S6k decreases mean lifespan by 34% at 29°C. Overexpression of a dominant-negative form of S6k protects mutants from deleterious effects of rich food, as if mimicking the effect of DR [15186745]. Fruit fly
    Factors are an extension of GenAge and GenDR.

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