Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast.

Authors: Aerts AM; Zabrocki P; Govaert G; Mathys J; Carmona-Gutierrez D; Madeo F; Winderickx J; Cammue BP; Thevissen K

Abstract: We previously isolated a Saccharomyces cerevisiae mutant (HsTnII), which displays 40% reduced chronological lifespan as compared to the wild type (WT). In this study, we found HsTnII cultures to be characterized by fragmented and dysfunctional mitochondria, and by increased initiation of apoptosis during chronological aging as compared to WT. Expression of genes encoding subunits of mitochondrial electron transport chain and ATP synthase is significantly downregulated in HsTnII, and as a consequence, HsTnII is not able to respire ethanol. All these data confirm the importance of functional mitochondria and respiration in determining yeast chronological lifespan and apoptosis.

Keywords: *Apoptosis/genetics; DNA Transposable Elements/genetics; Gene Expression; Hydrogen Peroxide/pharmacology; Mitochondria/*physiology/ultrastructure; Protein-Serine-Threonine Kinases/genetics/metabolism; Saccharomyces cerevisiae/genetics/*physiology/ultrastructure; Saccharomyces cerevisiae Proteins/genetics/metabolism
Journal: FEBS letters
Volume: 583
Issue: 1
Pages: 113-7
Date: Dec. 9, 2008
PMID: 19059240
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Citation:

Aerts AM, Zabrocki P, Govaert G, Mathys J, Carmona-Gutierrez D, Madeo F, Winderickx J, Cammue BP, Thevissen K (2009) Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast. FEBS letters 583: 113-7.


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