Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
| ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
|---|---|---|---|---|---|---|---|---|---|---|
| 123 | Cellular liver sterol content increases | 10116 | [Fusheng Tang, personal communication | — | liver | age | old | young | — | Overall the total cellular sterol content in liver increases with age [Fusheng Tang, personal communication]. |
| 124 | Reduced expression of autophagy genes | 7227 | — | 18059160 | neural | age | old | young | — | The expression of several autophagy genes is reduced in neural tissues as a normal part of aging [18059160]. |
| 125 | Insoluble ubiquitinated proteins accumulate | 7227 | — | 18059160 | neuronal | age | old | young | — | Insoluble ubiquitinated proteins, markers of neuronal aging and degeneration, accumulate with aging in concomitantly with the age-dependent suppression of autopagy [18059160]. |
| 126 | Elevated long-chain lactosylceramides | 9606 | — | 21687659 | fibroblasts | age | old | young | — | Long-chain lactosylceramides (LacCers) are significantly elevated in human fibroblasts isolated from elderly individuals [21687659]. |
| 130 | Melatonin decreases | — | — | 18212404 | — | age | old | young | — | Melatonin level decrease with age [reviewed in 18212404]. |
| 121 | Smaller body size | 6239 | — | 22810224 | — | mutation | eat-2 | wild-type | — | eat-2 mutants are noticeable smaller than wild-type [22810224]. |
| 1 | ROS production increases | 4932 | Laun et al., 2001 | 11251834 | — | Age | young | old | — | — |
| 122 | Lysosomal cholesterol content decreases | 10116 | Fusheng Tang, personal communication | — | liver | age | young | old | — | In rat liver cells, the content of cholesterol in the lysosomal membrane decreases with age in spite of the overall increase of total cellular sterols. |
| 98 | Shift in metabolism towards increasing fatty acid syntheses and breakdown | 7227 | Katewa et al. 2012 | — | muscle | diet | DR (0.5% yeast extract) | AL (5% yeast extract) | female/male | Flies on DR shift their metabolism toward increasing fatty acid synthesis and breakdown, specifically in muscle tissues, which is required for varoius responses to DR [22768842]. |
| 100 | Increase in steady-state triglyceride content | 7227 | Katewa et al. 2012 | — | — | diet | DR (0.5% yeast extract) | AL (5% yeast extract) | female/male | Flies on DR exhibit an increase in steady-state levels of triglyceride content [22768842]. |
| 104 | Hsp12 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Hsp12 levels [Herbert et al. in press]. |
| 105 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Eno1 levels [Herbert et al. in press]. |
| 106 | Hxk1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Hxk1 levels [Herbert et al. in press]. |
| 107 | Rtc3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Rtc3 levels [Herbert et al. in press]. |
| 108 | Rgil induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Eno1 levels [Herbert et al. in press]. |
| 109 | Sbp1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Sbp1 levels [Herbert et al. in press]. |
| 110 | Yef3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | Moderate DR upregulates Yef3 levels [Herbert et al. in press]. |
| 111 | Ctt1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Ctt1 levels [Herbert et al. in press]. |
| 112 | Eno1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Eno1 levels [Herbert et al. in press]. |
| 113 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
| 114 | Fba1 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Fba1 levels [Herbert et al. in press]. |
| 115 | Hsp26 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Hsp26 levels [Herbert et al. in press]. |
| 116 | Hsp31 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Hsp31 levels [Herbert et al. in press]. |
| 117 | Lys9 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Lys9 levels [Herbert et al. in press]. |
| 118 | Rtc3 induction | 4932 | Herbert et al. in press | — | — | diet | DR (0.5% glucose) | AL (2% glucose) | — | High osmolarity upregulates Rtc3 levels [Herbert et al. in press]. |
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