Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
2 Downregulation of exo-3 6239 Schlotterer et al., 2010 20346071 Whole body Age
41 Mitochondrial dysfunction increases 9606 Petersen et al., 2003 12750520 muscle Age Aging is accompanied by an increase in mitochondrial dysfunction in muscle of humans [12750520].
50 Vitamin D3 declines 9606 As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically.
62 Fertility declines 6239 20041217 whole body age females Fertility and reproduction sharply decline in early/mide-adulthood, folloed by a long post-reproductuve period, followed by a long-post-reproductive period [6,7 in 20041217].
63 Fertility declines 9606 20041217 whole body age females Female fertility declines in the mid-adulthood and reproduction ceases, followed by a long post-reproductive period [Refs in 20041217].
65 Protein expression variation increases 4932 Levy et al., 2012 age Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
66 Tsl1 abundance increases 4932 Levy et al., 2012 age Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012].
68 Increase in upper and central body fat deposition 9606 2921472 age There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472].
70 IGF1 levels decline 9606 3322823 plasma age A decline in IGF1 expression occurs with age progression. Levels of circulating IGF1 in humans are low at birth, rise progressively during childhood and peak during midadolescence, and then progressively fall as a function of age. Reduction in levels of circulating IGR1 is related to decreased secretion of growth hormone [3322823].
71 Telomere shortening 10090 22585399 age Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880].
72 IGF2 level changes 9606 3322823 plasma age Circulating IGF2 reaches “adult” levels early in childhood, and changes are relatively small as a function of increasing age [3322823].
73 p16 expression increases 10090 age p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
74 Reduced regenerative capacity Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
75 Metabolic and mitochondrial decline 10090 22585399 age males/females 2 years old mice exhibit metabolic and mitochondrial decline [22585399].
76 OSH5 upregulation 4932 Gebre et al. unpublished age OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
77 Osh6 downregulation Gebre et al., unpublished age Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].
78 Sir2 decline 4932 21436897 age Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897].
79 Vacuolar membrane deteriorates 4932 18690010 age The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010].
80 Cisd2 expression declines 22661501 age Cisd2 expression decreases with age [22661501].
81 elt-5 expression increases 6239 17608836 17608836 age Expression of elt-5 increases with during devleopment and aging [17608836].
82 elt-6 expression increases 6239 17608836 age Expression of elt-6 increases during devleopment and aging [17608836].
83 elt-3 expression increases 6239 17608836 age Expression of elt-3 increases during devleopment and aging [17608836].
84 Cell proliferation increases 1016 11744049 Diet 24 month DR in rats enhances cell proliferation in duodenum and forestomach mucosal tissue [11744049].
85 Cell proliferation decreases 10116 11744049 Diet 24 month DR in rats inhibits cell proliferation in glandular stomach and liver tissue [11744049].
88 Structural chromosome variation 9606 Acquired differences in structural chromosome variants between members of monozygoutic twin pairs (including mosaic anomalis) are observed in pairs of >55 years of age but not in younger [29 in Laurie et al. 2012].
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