Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
43 Follicle stimulating hormone increases 9606 Jeff Age 40 year male and emale Follicle stimulating hormone increases dramatically and becomes much more bioactive after the age of 40 in both men and women.
44 Luteneinzing hormone increases 9606 Jeff Age 40 year male and female Luteneizing hormone increases dramatically and becomes much more bioactive after the age 40 in both mena nd women.
45 human chorionic gonadotrophin increases 9606 Jeff Age 40 year male and female human chorionic gonadotrophin hCG increases in both men and women after age 40.
46 DHEA declines 9606 Jeff 70 male
47 Melatonin declines 9606 Age 70/35 year male/female Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)).
48 Growth hormone declines 9606 Age 70/35 year male/female
49 Progesterone declines 9606 Age 70/35 year male/female
50 Vitamin D3 declines 9606 As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically.
58 Hippocampal atrophy 9606 Hippocampus age 56 84 males/females Shrinkage of hippocampus occurs with age. Several genes and genomic loci are associated with this process, among them are genes implicated in cell death (HRK), embryonic development (WIF1), diabetes (DPP) and neuronal migration (ASTN2) [22504421;22504417].
59 Deteriorarition of circadian rhytms 10090 Farajnia, et al 2012 Suprachiasmatic Nucleus age 2 month 30 month Aged mice have disrupted sleep hevaiour and weakened brain network activity in the SCN. Aged SCN neurons lack day-night rhythms in some membrane properties. There is an age-related reductions of certain potassium currents that are import to the neuron’s rhythmic firing. Behavioral and sleep-wake rhythms exhibit a strong fragmentation, starting at the age of 700 d. Aged mice are deficient in membrane properties and GABAergic postsynaptic current amplitude. Aging mice selectively loss circadian modulation of fast-delayed-rectifer and A-type K+ currents. In aged mice at the tissue level, the phase synchrony of SCN neurons was grossly disturbed, with some subpopulations peaking in anti-phase and a reduction in amplitude of the overall multiunit activity rhythm.
63 Fertility declines 9606 20041217 whole body age females Female fertility declines in the mid-adulthood and reproduction ceases, followed by a long post-reproductive period [Refs in 20041217].
64 Decrease in WNT gene expression 9606 RoSyBa 2011 adipose-derived stem cells age 40 year 60 year females A dramtic decrease in WNT gene expression occurs in Adipose-dreived stem cells from females at the age of 40-60 years [RoSyBa 2011].
65 Protein expression variation increases 4932 Levy et al., 2012 age Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
66 Tsl1 abundance increases 4932 Levy et al., 2012 age Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012].
73 p16 expression increases 10090 age p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
74 Reduced regenerative capacity Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
76 OSH5 upregulation 4932 Gebre et al. unpublished age OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
77 Osh6 downregulation Gebre et al., unpublished age Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].
84 Cell proliferation increases 1016 11744049 Diet 24 month DR in rats enhances cell proliferation in duodenum and forestomach mucosal tissue [11744049].
86 Clonal mosicaism frequency increases 9505 Hunter et al. 2012 blood 50 79 female/male Detectable clonal mosaicism frequency in peripheral blood is low (<0.5 %) from birth until 50 years of age, after which it rapidley rises to 2-3% in the elderly. The frequency of mosic abnormalities increases with age, from 0.23% under 50 years to 1.91% between 75 and 79 years [Hunter et al. 2012].
88 Structural chromosome variation 9606 Acquired differences in structural chromosome variants between members of monozygoutic twin pairs (including mosaic anomalis) are observed in pairs of >55 years of age but not in younger [29 in Laurie et al. 2012].
89 Chromosomal anomalies 969 age Chromosomal anomalies (rearrangements and aneuploidies) during cell division increases with age in cultured lymphocytes and fibroblasts [30,31 in Lauri et al. 2012].
90 Accumulation of DNA damage 10090 age DNA damage accumulates with age in mouse hematopoietic stem cells [32 in Lauri et al. 2012].
95 Ceramides increase age Sphingosine-linked fatty acids like ceramides serve as "damage-associated molecular patterns" (DAMPs) are increased in aged tissue and cause inflammatory damage via activation of Nlrp3 inflammasome [Vandanmagsar et al. 2011; Youm et al. 2012].
97 Diminished cognitive skills 9606 age Cognitive skill such as learning and memory diminish with age [http://www.sciencedaily.com/releases/2012/06/120629211902.htm].
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