Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:
ID | name | taxid | reference | pmid | tissue | comparision | start | stop | gender | description |
---|---|---|---|---|---|---|---|---|---|---|
52 | DHEA decreases | 9606 | Hinson and Raven, 1999 | 10495400 | serum | age | 25 year | 85 year | males/females | DHEAS (Dehydroepiandrosterone sulphate) is the most abundant circulating steroid secreted by adrenal glands. Duo to its position int the steroid cascade DHEA act like kind of âthe mother steroidâ (Regelson et al., 1994). DHEA reaches its highest levels at age 20-24. Its serum concentration declines with increasing age after 25 years and diminishes about 95% by 85 years. DHEA deficiency syndrome is a new term for old age [10495400]. |
53 | DHEA increases | 9606 | Hinson and Raven, 1999 | 10495400 | serum | age | 10 year | 20 year | males/females | DHEA reaches its highest levels at age 20-24 [10495400]. |
54 | DHEA decreases | 9544 | Lane et al., 1997 | 9215277 | serum | Age | 5 year | 26 year | males/females | Males and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. The proportional age-related loss of DHEAS in rhesus moneys is over twice the rate of decline observed in humans [9215277]. |
55 | DHEA deline slows | 9544 | Lane et al., 199 | 9215277 | serum | diet | DR | — | males/females | DR slows postmaturational decline in serum DHEAS levels form the age of 6.5 to 9.5 [9215277]. |
56 | Ability to make decisions in novel sitations decreases | 9606 | Samanez-Larkin et al., 2012 | 22496578 | — | age | 21 year | 85 year | males/females | The ability to make decisions in novel sitations decreases with age from 21 to 85 years [22496578]. |
57 | White matter integrity decreases | 9606 | Samanez-Larkin et al., 2012 | 22496578 | white matter | age | 21 year | 85 year | males/females | Older age is associated with decreased reward learning and decreased white matter integrity in specific pathways running form the thalamus to the medial prefrontal cortex and from the meial prefrontal cortex to the ventral stratium |
58 | Hippocampal atrophy | 9606 | — | — | Hippocampus | age | 56 | 84 | males/females | Shrinkage of hippocampus occurs with age. Several genes and genomic loci are associated with this process, among them are genes implicated in cell death (HRK), embryonic development (WIF1), diabetes (DPP) and neuronal migration (ASTN2) [22504421;22504417]. |
75 | Metabolic and mitochondrial decline | 10090 | — | 22585399 | — | age | — | — | males/females | 2 years old mice exhibit metabolic and mitochondrial decline [22585399]. |
47 | Melatonin declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)). |
48 | Growth hormone declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | — |
49 | Progesterone declines | 9606 | — | — | — | Age | 70/35 year | — | male/female | — |
44 | Luteneinzing hormone increases | 9606 | Jeff | — | — | Age | 40 year | — | male and female | Luteneizing hormone increases dramatically and becomes much more bioactive after the age 40 in both mena nd women. |
45 | human chorionic gonadotrophin increases | 9606 | Jeff | — | — | Age | 40 year | — | male and female | human chorionic gonadotrophin hCG increases in both men and women after age 40. |
43 | Follicle stimulating hormone increases | 9606 | Jeff | — | — | Age | 40 year | — | male and emale | Follicle stimulating hormone increases dramatically and becomes much more bioactive after the age of 40 in both men and women. |
3 | HDL decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
4 | HDL decrease | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
5 | HDL increases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
6 | VLDL decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
7 | VLDL decrease | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
8 | VLDL decrease | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
9 | LDL decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Diet | 30% DR for 48h at 16 weeks | — | male | — |
10 | LDL decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1-/- at 16 weeks | — | male | — |
11 | Valine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
12 | Isoleucine decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
13 | Lactate decreases | 10090 | Wijeyesekera et al., 2012 | 22225495 | Plasma | Mutant | Irs1df/df at 16 weeks | — | male | — |
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