Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
65 Protein expression variation increases 4932 Levy et al., 2012 — — age — — — Transcripts tha become over- or under-expressed in old cells tend to result in protein levels that are more variable across cells in exponential growth [Levy et al., 2012].
77 Osh6 downregulation — Gebre et al., unpublished — — age — — — Total cellular Osh6 levels decrease in aged cells. Osh6 in mid-aged cells is less than half of the Osh6 levels in young cells [Gebre et al., unpublished].
68 Increase in upper and central body fat deposition 9606 — 2921472 — age — — — There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472].
79 Vacuolar membrane deteriorates 4932 — 18690010 — age — — — The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010].
124 Reduced expression of autophagy genes 7227 — 18059160 neural age old young — The expression of several autophagy genes is reduced in neural tissues as a normal part of aging [18059160].
56 Ability to make decisions in novel sitations decreases 9606 Samanez-Larkin et al., 2012 22496578 — age 21 year 85 year males/females The ability to make decisions in novel sitations decreases with age from 21 to 85 years [22496578].
95 Ceramides increase — — — — age — — — Sphingosine-linked fatty acids like ceramides serve as "damage-associated molecular patterns" (DAMPs) are increased in aged tissue and cause inflammatory damage via activation of Nlrp3 inflammasome [Vandanmagsar et al. 2011; Youm et al. 2012].
78 Sir2 decline 4932 — 21436897 — age — — — Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897].
58 Hippocampal atrophy 9606 — — Hippocampus age 56 84 males/females Shrinkage of hippocampus occurs with age. Several genes and genomic loci are associated with this process, among them are genes implicated in cell death (HRK), embryonic development (WIF1), diabetes (DPP) and neuronal migration (ASTN2) [22504421;22504417].
93 Tetracosahexaenoic acid decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of Tetracosahexaenoic acid decrease from 3 to 22 months [22661299].
92 SM(d18:1/12:0) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of SM(d18:1/12:0) decreasefrom 3 to 22 months [22661299].
91 LysoPC(18:4) decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of LysoPC(18:4) decrease from 3 to 22 months [22661299].
94 7alpha-dihydroxy-4-cholesten-4-one decrease 10090 — 22661299 serum age 3 months 22 months female Serum levels of 7alpha-dihydroxy-4-cholesten-4-one decreases from 3 to 33 months [22661299].
66 Tsl1 abundance increases 4932 Levy et al., 2012 — — age — — — Replicative age correlates with a Tsl1-abundant cell state [Levy et al., 2012].
60 Protein aggregation 6239 — 22103665 whole body age 1 day 11 day hermaphrodites protein aggreation accumulate in aged animals. Hundrets of protein are enriched in an SDS-insoluble fraction in aged nematode adn alre largely absent from similiar protein fraction in young nematodes. Genes encoding proteins that become insoluble with age are enriched for modifiers of lifespan [22103665].
87 LysoPC(16:1) decrease 10090 — 22661299 — — 3 months 12 momths — Plasma levels of LysoPC(16:1) decreases with age from 3 to 22 months [22661299].
73 p16 expression increases 10090 — — — age — — — p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
123 Cellular liver sterol content increases 10116 [Fusheng Tang, personal communication — liver age old young — Overall the total cellular sterol content in liver increases with age [Fusheng Tang, personal communication].
76 OSH5 upregulation 4932 Gebre et al. unpublished — — age — — — OSH5 level is up-regulated during aging by about 3-15-fold [Gebre et al. unpublished].
57 White matter integrity decreases 9606 Samanez-Larkin et al., 2012 22496578 white matter age 21 year 85 year males/females Older age is associated with decreased reward learning and decreased white matter integrity in specific pathways running form the thalamus to the medial prefrontal cortex and from the meial prefrontal cortex to the ventral stratium
51 DHEA increases 9606 Willcox et al., 2007 17986602 serum diet Okinawa — — Okinawa aged 65-plus have relatively high DHEA levels.
96 Loss of histone proteins from the genome 4932 — 20832724 — age — — — Normal aging is accompanied by a profound loss of histone proteins from the genome [20832724].
110 Yef3 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Yef3 levels [Herbert et al. in press].
109 Sbp1 induction 4932 Herbert et al. in press — — diet DR (0.5% glucose) AL (2% glucose) — Moderate DR upregulates Sbp1 levels [Herbert et al. in press].
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