Denigma Buck Institute Health Extension
Polymorphism: rs2275075
rs2275075 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 1q22

Factor:
- Symbol: LMNA
- Name: lamin A/C
- Entrez ID: 4000
- Ensembl ID: ENSG00000160789

Factors:
  • LMNA lamin A/C ( 4000 / ENSG00000160789 )


    • Description:

    There were no significant single-SNP associations with longevity after correction for multiple testing via permutation tests. However, there was an observed association with longevity involving the GTCT haplotype of SNPs rs915179, rs2485662, rs4641, and rs1468772

    Ethnicity: American, Caucasian
    Age of cases: Mean age 101.5
    Finding: Negative

    Statistics
    - Number of cases/controls: 873 vs 443 (initial) | New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication)
    - p-value: 0.54
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: Meta-analysis

    Reference:
    22340368: Human longevity and common variations in the LMNA gene: a meta-analysis.

    Choice: Clean
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 9, 2014, 11:43 p.m.

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