Denigma Buck Institute Health Extension
Polymorphism: rs1002149
rs1002149 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 8p21.1

Factor:
- Symbol: GSR
- Name: glutathione reductase
- Entrez ID: 2936
- Ensembl ID: ENSG00000104687

Factors:
  • GSR glutathione reductase ( 2936 / ENSG00000104687 )

    • Ethnicity: Danish
    Age of cases: 92-93 years old
    Shorter lived allele: A
    Longer lived allele: C
    Finding: Positive

    Statistics
    - Number of cases/controls: 1089 vs 736 (initial) | 1613 vs 1104 (replication)
    - Odds ratio: 0.706
    - p-value: 0.0335 [0.0335]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Illumina GoldenGate platform

    Reference:
    22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

    Choice: Curate_Emily
    Created: July 1, 2013, 10:43 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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