Polymorphism: rs4646994
rs4646994
(
SNPedia |
23andMe
)
Variant Type: STR
Location: 17q23.3
Factor:
- Symbol: ACE
- Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Entrez ID: 1636
- Ensembl ID: ENSG00000159640
Factors:
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
(
1636
/
ENSG00000159640
)
Description:
ACE Alu D/I polymorphism.
The D/D genotype is associated with mortality only in men. In a Chinese elderly population, ACE polymoprhism may be considered deleterious
to longevity, the D/D genotype being associated with mortality, the atherosclerotic process, hypertension and myocarial_infarction. There are gender differences in the relationship between D/D genotype and cardivascular disease and mortality.
Ethnicity:
Chinese
Age of cases: Minimum age 65
Shorter lived allele: DD
Finding: Positive
Statistics
- Number of cases/controls: 4000 (initial)
- p-value:
0.05
[0.05]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR & gel electropheresis
Reference:
22456784: The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population.
Choice: Clean
Created: July 1, 2013, 10:04 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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