Denigma Buck Institute Health Extension
Polymorphism: rs429358, rs7412
rs429358, ( SNPedia | 23andMe )
rs7412 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 19q13.2

Factor:
- Symbol: APOE
- Name: apolipoprotein E
- Entrez ID: 348
- Ensembl ID: ENSG00000130203

Factors:
  • APOE apolipoprotein E ( 348 / ENSG00000130203 )


    • Description:

    Cases were offspring of centenarians, controls - their spouses

    Ethnicity: American, Danish
    Age of cases: Mean age 60.2
    Shorter lived allele: e4
    Longer lived allele: e2
    Finding: Positive

    Statistics
    - Number of cases/controls: 2307 vs 764 (initial)
    - Odds ratio: 0.75
    - p-value: 0.005 [0.005]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    23040522: Apolipoprotein E and familial longevity.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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