Polymorphism: rs3772190
rs3772190
(
SNPedia |
23andMe
)
Variant Type: SNP
Location: 5p15.33
Factor:
- Symbol: TERC
- Name: telomerase RNA component
- Entrez ID: 7012
Factors:
TERT
telomerase reverse transcriptase
(
7015
/
ENSG00000164362
)
Description:
"... although the finding did not remain significant after Bonferroni step-down correction (P-corrected = 0.108 using a dominant model and P = 0.153 for comparison of GG vs. AG). If instead applying the less conservative Benjamini and Hochberg correction method, the P-values were 0.108 for the dominant model and 0.081 for GG vs. AG, respectively"
Ethnicity:
Danish
Shorter lived allele: A
Longer lived allele: G
Finding: Positive
Statistics
- Number of cases/controls: 1013 total (initial)
- p-value:
0.006
[0.006]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: TaqMan SNP genotyping assays
Reference:
22136229: Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.
Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
Edit
(
Admin) |
Delete