Denigma Buck Institute Health Extension
Polymorphism: rs1800775
rs1800775 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 16q21

Factor:
- Symbol: CETP
- Name: cholesteryl ester transfer protein, plasma
- Entrez ID: 1071
- Ensembl ID: ENSG00000087237

Factors:
  • CETP cholesteryl ester transfer protein, plasma ( 1071 / ENSG00000087237 )


    • Description:

    "Compared with the −629 wild-type (CC), the heterozygous (CA) and homozygous (AA) genotypes were associated with a stepwise reduction in risk of overall mortality of 6% (HR: 0.94, 95% CI: 0.87 to 1.02) and 10% (HR: 0.90, 95% CI: 0.82 to 0.98)"

    Ethnicity: Danish
    Age of cases: 20-93, followed for up to 34 years
    Shorter lived allele: CC
    Longer lived allele: non-CC
    Finding: Positive

    Statistics
    - Number of cases/controls: 10261 (initial)
    - p-value: 0.02 [0.02]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Not described

    Reference:
    23083790: Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects.

    Choice: Clean
    Created: Aug. 25, 2013, 7:54 p.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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