| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
| AAT M/Z/S | AAT | 0.18 | 1e-07 | 143 vs 255 vs 127 | — | Italian | Centenarians | M, S | Z | Candidate Region/Gene | 17048073 |
| VNTR in intron 5 (DeltaEF1 site) | SIRT3 | — | 8e-05 | 242 vs 703 | — | Italian | Median age 102 | 2b | — | Candidate Region/Gene | 15676284 |
| --1082G-->A | IL10 | — | 0.0001 | 109 (oldest old men) vs 263 (healthy controls) | — | Italian | >95 | A | — | Candidate Region/Gene | 15466015 |
| rs8052394 | MT1a | 2.16 | 0.0002 | 151 vs 100 | — | Italian | Mean age 91.4 +/- 4.1 | — | A | Candidate Region/Gene | 16955215 |
| rs1805097 | IRS2 | 2.03 | 0.0003 | 144 vs 418 | — | Italian | 85-100 years old | non-AA | AA | Candidate Region/Gene | 19887537 |
| rs1800896 | IL-10 | 3.00 | 0.0003 | 142 vs 153 | — | Italian | Mean age 67 | AA | GG | Candidate Region/Gene | 15466015 |
| rs16928120 | — | — | 0.00057 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
| G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination | — | 3.19 | 0.0006 | 208 vs 514 | — | Italian | Mean age 96 | non-AAV allele combi | AAV allele combinati | Candidate Region/Gene | 21340542 |
| K153R | MSTN | 3.48 | 0.001 | 156 vs 384 | 79 vs 316 | Italian, Spaniard | 100–111 | K | — | Candidate Region/Gene | 23354683 |
| APOE polymorphism | APOE | 3.26 | 0.001 | 64 vs 1344 | — | Italian | 100+ | e4 | e2 | Candidate Region/Gene | 16960022 |
| 3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) | HRAS | 1.13 | 0.002 | 234 vs 467 | — | Italian | centenarians | a3 allele (see notes) | — | Candidate Region/Gene | 11943467 |
| APOE polymorphism | APOE | 0.38 | 0.002 | 200 (cases) vs 539 | — | Italian | >88 | e4 | e2 | Candidate Region/Gene | 21703254 |
| rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 | CDKN1A | — | 0.00211 | 184 vs 184 | — | Italian | 100 | non G-G-G-C-C-G haplotypes | G-G-G-C-C-G | Candidate Region/Gene | 20126416 |
| rs4073591 | DEAF1 | — | 0.002618 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
| rs2802288 | FOXO3A | 1.51 | 0.003 | 281 vs 195 | — | Italian | 90–108 | G | A | Candidate Region/Gene | 19415983 |
| ADA genotypes | ADA | — | 0.003 | 62 vs 64 vs143 vs 272 | — | Italian | Minimum age 90 | ADA*2 | non-ADA*2 | Candidate Region/Gene | 20174870 |
| VNTR (Variable Number of Tandem Repeats) | APOB | — | 0.003 | 143 vs 158 | — | Italian | mean age is 102 years | 35 or more tandem repeats | — | Candidate Region/Gene | 9050915 |
| S61712.1 (GenBank, 3` VNTR) | — | — | 0.003 | 143 (51 m, 92 f) vs 158 (77 m, 81 f) | — | Italian | 102 +/- 2 | <35 repeats | — | Candidate Region/Gene | 9050915 |
| rs1764391 | GJA4 | — | 0.0035 | 56 vs 196 (males) | — | Italian | >99 | — | CC | Candidate Region/Gene | 16970956 |
| rs3176343-rs3176344-rs3176349-rs1801270 | CDKN1A | — | 0.00394 | 184 vs 184 | — | Italian | 100 | non G-G-G-C haplotypes | G-G-G-C | Candidate Region/Gene | 20126416 |
| rs4073590 | DEAF1 | — | 0.004259 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
| (A/C)−110 | HSP70-1 | 0.40 | 0.005 | 120 vs 471 | — | Italian | 100 years and above | A | — | Candidate Region/Gene | 14501185 |
| HUMTHO1.STR | TH | 0.85 | 0.005 | 210 vs 755 | — | Italian | 100+ | — | 10* (imperfect allele 10) | Candidate Region/Gene | 12297342 |
| rs73598374 | ADA | 0.32 | 0.0056 | 97 vs 261 | — | Italian | >88 | G*/G* | A*+ | Candidate Region/Gene | 21865054 |
| rs11040489 | KRTAP5-6 | — | 0.005869 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
