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| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| HRAS1 LASS1 (CGT) | APOE | — | 1.06e-09 | 68 vs 68 | — | American | — | — | — | Candidate Region/Gene | 20569235 |
| E2 / E3 / E4 | APOE | — | 1.2e-08 | 560 vs 560 | — | French | centenarians 100th year or beyond, mean age 103.1 | E4 | — | Candidate Region/Gene | 11280044 |
| DRD4 7R allele | DRD4 | — | 3.5e-08 | 310 vs 2909 | — | European | mean age 95.2 years | — | — | Candidate Region/Gene | 23283341 |
| AAT M/Z/S | AAT | 0.18 | 1e-07 | 143 vs 255 vs 127 | — | Italian | Centenarians | M, S | Z | Candidate Region/Gene | 17048073 |
| HFE C282Y | HFE | — | 7.2e-07 | 35 vs 106 | — | 91-105 (< 50 versus >90) | C | Y | Candidate Region/Gene | 11857056 | |
| rs507879 | CASP5 | — | 1.4e-05 | 510 vs 549 | — | Russian | 75–103 | AG | AA, GG | Candidate Region/Gene | 20434535 |
| rs4946936 | FOXO3 | 1.40 | 1.8e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | T | C | Candidate Region/Gene | 19793722 |
| rs1042718-rs1042719 | ADRB2 | 0.63 | 1.86e-05 | 384 vs 384 | 579 vs 644 | Chinese | Mean age 102.1±0.20 | G-C | A-C | Candidate Region/Gene | 23020224 |
| rs2802292 | FOXO3 | 1.36 | 2.9e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | G | T | Candidate Region/Gene | 19793722 |
| rs2755213 | FOXO1 | 0.75 | 7.4e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | C | T | Candidate Region/Gene | 19793722 |
| rs2253310 | FOXO3 | 1.35 | 7.9e-05 | 761 vs 1056 | 350 vs 350 | Chinese | mean age 102.3 | C | G | Candidate Region/Gene | 19793722 |
| VNTR in intron 5 (DeltaEF1 site) | SIRT3 | — | 8e-05 | 242 vs 703 | — | Italian | Median age 102 | 2b | — | Candidate Region/Gene | 15676284 |
| rs2542052 | APOC3 | — | 0.0001 | 213 old vs 216 offspring vs 258 controls | — | Ashkenazi Jewish | 100+ | A | — | Candidate Region/Gene | 16602826 |
| rs12050077 | TSHR | 1.68 | 0.0001 | 232 vs 163 | — | Ashkenazi Jewish | Median age 97 | G | A | Candidate Region/Gene | 19837933 |
| rs1207362 | KL | 0.63 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | C | Candidate Region/Gene | 22406557 |
| rs2267723 | GHRHR | 0.70 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | G | A | Candidate Region/Gene | 22406557 |
| rs3842755 | INS | 1.79 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | C | A | Candidate Region/Gene | 22406557 |
| rs11571461 | RAD52 | 2.23 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92-93 years old | A | G | Candidate Region/Gene | 22406557 |
| APOE polymorphism | APOE | — | 0.0001 | 291 vs 589 | — | Finn | Mean age 97.5 | e4 | e2 | Candidate Region/Gene | 16487435 |
| APOE haplotype - rs1346044 | APOE | — | 0.0001 | 175 vs 178 | — | Finn | 100.8 | e4 | e2 | Candidate Region/Gene | 10069711 |
| --1082G-->A | IL10 | — | 0.0001 | 109 (oldest old men) vs 263 (healthy controls) | — | Italian | >95 | A | — | Candidate Region/Gene | 15466015 |
| rs2542052 | APOC3 | — | 0.0001 | Centenarians (n = 213) their offspring (n = 216) vs 258 | — | Ashkenazi Jewish | mean age 98.2 | A | — | Candidate Region/Gene | 16602826 |
| rs2802292 | FOXO3 | — | 0.0001 | 213 vs 402 | — | Japanese | minimum 95; mean 97.9 | T | — | Candidate Region/Gene | 18765803 |
| rs3842755 | INS | 1.79 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92.2–93.8 (mean age 93.2 | C | — | Candidate Region/Gene | 22406557 |
| rs1207362 | KL | 0.63 | 0.0001 | 1089 vs 736 | 1613 vs 1104 | Danish | 92.2–93.8 (mean age 93.2 | A | — | Candidate Region/Gene | 22406557 |