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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
Danish «
American (2)
Dutch (2)
French (1)
German (12)
Italian (1)
Tatar (1)
Study type:
+
-
‑ (1)
Candidate Region/Gene (83)
Variant type:
+
-
SNP (51)
Haplotype (2)
STR (1)
(1)
Variant effect:
+
-
Longevity‑Associated (57)
No Age Effect (22)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
rs11235972
UCP3
—
0.029
908 vs 708
—
Danish
93
A
—
Candidate Region/Gene
22743239
rs1685354
UCP3
—
0.762
908 vs 708
—
Danish
93
—
—
Candidate Region/Gene
22743239
rs3781907
UCP3
—
0.05
908 vs 708
—
Danish
93
G
—
Candidate Region/Gene
22743239
rs647126
UCP3
—
0.447
908 vs 708
—
Danish
93
—
—
Candidate Region/Gene
22743239
ACE D/I
ACE
—
0.02
689
—
Danish
Minimum age 73
II
DI, DD
Candidate Region/Gene
12547486
rs11235972
UCP3
—
0.029
908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT))
—
Danish
93
A
—
Candidate Region/Gene
22743239
rs3781907
UCP3
—
0.05
908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT))
—
Danish
93
G
—
Candidate Region/Gene
22743239
rs201058276
F7
0.68
0.01
187 vs 201
—
Danish
centenarians
R
—
Candidate Region/Gene
11602206
323ins10
F7
0.69
0.01
187 vs 201
—
Danish
centenarians
323P0
—
Candidate Region/Gene
11602206
rs4880
SOD2
0.91
0.002
1650
—
Danish
All danes born in 1905 (Danish 1905 cohort)
T
—
Candidate Region/Gene
19428448
rs1050450
GPX1
0.93
0.008
1613
—
Danish
All danes born in 1905 (Danish 1905 cohort)
C
—
Candidate Region/Gene
19428448
rs9486902
FOXO3
1.40
0.0118
1089 vs 736
—
Danish
92–93
C
—
Candidate Region/Gene
20849522
rs12206094
FOXO3
1.38
0.0076
1089 vs 736
—
Danish
92–93
C
—
Candidate Region/Gene
20849522
rs2802292
FOXO3
1.34
0.0078
1089 vs 736
—
Danish
92–93
T
—
Candidate Region/Gene
20849522
rs13220810
FOXO3
0.75
0.0223
1089 vs 736
—
Danish
92–93
C
—
Candidate Region/Gene
20849522
rs2764264
FOXO3
—
0.05
1089 vs 736
—
Danish
92–93
T
—
Candidate Region/Gene
20849522
rs7762395
FOXO3
—
0.05
1089 vs 736
—
Danish
92–93
G
—
Candidate Region/Gene
20849522
rs13217795
FOXO3
—
0.05
1089 vs 736
—
Danish
92–93
T
—
Candidate Region/Gene
20849522
rs9400239
FOXO3
—
0.05
1089 vs 736
—
Danish
92–93
C
—
Candidate Region/Gene
20849522
rs9398172
FOXO3
—
0.05
1089 vs 736
—
Danish
92–93
A
—
Candidate Region/Gene
20849522
rs3800231
FOXO3
1.26
0.0495
1089 vs 736
—
Danish
92–93
G
—
Candidate Region/Gene
20849522
rs479744
FOXO3
—
0.05
1089 vs 736
—
Danish
92–93
(can't figure out using ensemble and NCBI)
—
Candidate Region/Gene
20849522
GSTT1 gene deletion
GSTT1
—
0.001
447
—
Danish
77.4
no deletion
deletion
-
16574194
rs2866164
MTTP
—
1.0
1651 vs 575
—
Danish
92-93
—
—
Candidate Region/Gene
16015282
rs2227956
HSPA1L
—
0.328
168 cases
—
Danish
Mean age 92.8 +/- 0.4
—
—
Candidate Region/Gene
20388090
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25 of 88 variants
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