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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
African European (1)
Australian (3)
Canadian (1)
Finn (16)
Georgian (4)
Human (4)
Multiethnic (19)
Sichuan (18)
Spanish (4)
American (303)
African American (2)
Amish (2)
Mexican (1)
Nigerian (1)
Tunisian (1)
Turkish (6)
Asian (1)
Chinese (104)
Japanese (61)
Okinawan (4)
Korean (17)
Brazilian (2)
Caucasian (388)
European (10)
British (61)
Polish (15)
Croatian (1)
Danish (88)
Dutch (87)
French (34)
German (134)
Greek (9)
Irish (16)
Italian (263)
Calabrian (1)
Calabrian (8)
Northern European (19)
Scottish (2)
Bulgarian (7)
Swiss (1)
Spaniard (12)
Hispanic (1)
Ashkenazi Jewish (38)
Jordanian (8)
Russian (4)
Tatar (1)
Study type:
+
-
GWAS (2)
‑ (27)
Candidate Region/Gene (784)
Meta‑Analysis (38)
Complete Mitochondrial Genome (2)
Whole‑Genome Linkage Scan (1)
Genome‑Wide Association Study (710)
Mitochondrial Haplogroup (36)
Mitochondrial genome (3)
Variant type:
+
-
SNP (572)
Locus (5)
Haplotype (87)
Other (1)
STR (11)
Deletion (5)
CNV (1)
(1)
VNTR (1)
Variant effect:
+
-
Longevity‑Associated (1027)
No Age Effect (543)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
mtDNA haplotype
—
—
0.0052
212 vs 275
—
Italian
100+
non-J haplogroups
—
Mitochondrial Haplogroup
10463944
55 (L/M)
PON1
0.94
0.44
308 vs 579 Italian, 296 vs 296 Irish
—
Irish
,
Italian
Italian 100.8 years, Irish 89.8 years
—
—
Candidate Region/Gene
15050299
192 (Q/R)
PON1
1.30
0.007
308 vs 579 Italian, 296 vs 296 Irish
—
Irish
,
Italian
Italian 100.8 years, Irish 89.8 years
Q
—
Candidate Region/Gene
15050299
apoE haplotypes
—
—
0.02
80 vs 391
—
Greek
80+
Apo e4
—
Candidate Region/Gene
17234815
?60H
LMP2
—
0.756
157 vs 311
—
Italian
88+
H
—
Candidate Region/Gene
11772516
?145K
LMP7
—
0.849
157 vs 311
—
Italian
88+
K
—
Candidate Region/Gene
11772516
apoE haplotypes
—
—
0.0042
3924
—
American
5-70
Apo e4
—
Candidate Region/Gene
21332925
rs11235972
UCP3
—
0.029
908 vs 708
—
Danish
93
A
—
Candidate Region/Gene
22743239
rs1685354
UCP3
—
0.762
908 vs 708
—
Danish
93
—
—
Candidate Region/Gene
22743239
rs3781907
UCP3
—
0.05
908 vs 708
—
Danish
93
G
—
Candidate Region/Gene
22743239
rs647126
UCP3
—
0.447
908 vs 708
—
Danish
93
—
—
Candidate Region/Gene
22743239
82133 G>A
—
—
0.0189
33 vs 39
—
Japanese
90+
A
—
Candidate Region/Gene
15820493
APOE e2/e3/e4
APOE
4.40
0.02
179
—
Finn
Minimum age 104
e3, e4
e2
Candidate Region/Gene
11213279
G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination
—
3.19
0.0006
208 vs 514
—
Italian
Mean age 96
non-AAV allele combi
AAV allele combinati
Candidate Region/Gene
21340542
rs2802288
FOXO3A
1.51
0.003
281 vs 195
—
Italian
90–108
G
A
Candidate Region/Gene
19415983
rs1800629
TNF
—
1.0
119 vs 118
—
Jordanian
Mean age 90.2
—
—
Candidate Region/Gene
20518833
rs1800896
IL10
—
0.031
119 vs 118
—
Jordanian
Mean age 90.2
G
A
Candidate Region/Gene
20518833
G1691A
F5
—
0.004
432 vs 184
—
Polish
Minimum age 95
A
G
Candidate Region/Gene
20720309
rs1799752
ACE
—
0.016
12 vs 190 vs 105
—
Greek
99-111
D
I
Candidate Region/Gene
23389097
rs708272
CETP
—
1.0
12 vs 190 vs 105
—
Greek
99-111
—
—
Candidate Region/Gene
23389097
rs5882
CETP
—
1.0
12 vs 190 vs 105
—
Greek
99-111
—
—
Candidate Region/Gene
23389097
H63D
HFE
—
1.0
35 vs 106
—
91-105
—
—
Candidate Region/Gene
11857056
S65C
HFE
—
1.0
35 vs 106
—
91-105
—
—
Candidate Region/Gene
11857056
-
Insulin signaling pathway (IIS)
—
0.01
403 vs 1670
—
European
90-103
—
—
Genome-Wide Association Study
22113349
-
Telomere maintenance pathway (TM)
—
0.02
403 vs 1670
—
European
90-103
—
—
Genome-Wide Association Study
22113349
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25 of 1635 variants
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